Regenerative Medicine

Injuries or blockages in hollow structures often require stents to keep the passage open to aid in treatment or to help during healing.

There is a major need for a smarter solution, one that provides strong support early on, then safely disappears once healing is complete.

This novel stent technology combines a flexible metallic scaffold with temporary, bioresorbable components that help secure the stent during the critical healing window.

- Adjunctive therapy in chronic muscle degenerative conditions characterized by impaired healing.

Tregs are known for their anti-inflammatory properties and their role in promoting tissue repair and regeneration.

- Targeted Immune Modulation: By specifically recruiting Tregs to the injury site, the technology leverages the body’s natural anti-inflammatory pathways to promote healing, reducing reliance on systemic immunosuppressive drugs.

This fast-acting probe has enabled real-time imaging of H2O2 produced in endothelial cells and in a zebrafish wound healing model, providing an accurate platform for endogenous H2O2 detection in real time with chemical probes.

Hydrogen peroxide mediates various biological processes such as wound healing, apoptosis, and inflammation.

The fast kinetics enabled real-time imaging of H2O2 produced in endothelial cells in 8 seconds (much earlier than previously shown) and H2O2 in a zebrafish wound healing model.

Lubricants for this purpose must form nanometer-thick layers, be thermally stable particularly during tribology contact, be load carrying and self-healing.

Secretome reduced fibrosis in wounded TM cells, increased TM cells’ wound healing capacity, and protected retinal ganglion cell from death.

These non-healing wounds reduce patients’ quality of life through pain, infection, sepsis, and amputation.

Nitrix is a new, low-cost biomaterial that treats the root causes of chronic wounds – inflammation and poor vascularization – to promote healing.

Compared to other ECM devices, Nitrix is no more costly or complicated to produce, and it offers greater healing capabilities.

- Supporting post-operative rehabilitation by providing continuous feedback on bone healing status following orthopedic surgeries.

This invention is a novel biodegradable polymer conduit designed to deliver therapeutic agents locally over extended periods to promote tissue regeneration and healing.

The double-walled architecture of the microspheres enables modulation of the release kinetics, thereby maintaining sustained delivery profiles suited to the physiological requirements of nerve tissue repair.

- Controlled, Sustained Drug Release: The double-walled microspheres provide prolonged, predictable release profiles, reducing dosing frequency and maintaining therapeutic agent bioavailability over critical healing periods.

University of Pittsburgh researchers have developed a novel laser surface texturing technology that fabricates defined micro grid patterns on endovascular metallic materials, such as Cobalt-Chromium (CoCr).

Notably, delivery of RADA-SP can result in significantly higher infiltration of vSMCs, indicating enhanced healing potential.

Additionally, metformin promotes angiogenesis which can reduce healing time and lead to enhanced tissue healing with high-quality tissue regeneration.

In vivo studies in mice with Achilles tendon injuries treated with intraperitoneal injections of metformin demonstrated that the treatment increased and activated AMPK while suppressing TGF-β1 levels within the healing tendon in acute injuries.

University of Pittsburgh researchers have discovered that metformin (Met), a commonly used medicine to treat type 2 diabetes, to promote soft tissue healing and prevent the development of fibrosis and resulting tendinopathy.

These properties ensure consistent mechanical performance during degradation, offering significant advantages for applications such as heart valve tissue engineering and broader soft tissue repair.

They stimulate local bone formation, enhancing healing and load-bearing capabilities.

Degradable, thermosensitive hydrogels could provide important benefits to tissue engineering and drug delivery applications.

The compelling data generated demonstrates superior healing, including the reduction of scar tissue, restoration of epidermal thickness to near-normal levels, and regeneration of hair follicles.