Department

Med-Pharmacology and Chemical Biology

Novel Mouse Models of Rare Genetic Disorder

05539

CRISPR-crafted mouse model of rare TPI deficiency enables mechanistic studies and therapeutic exploration for this childhood neurodegenerative disorder.

Technology Type: Life Science Research Tool
Technology Subtype: Animal Model
Therapeutic Areas: Endocrinology and Metabolic Diseases
Rare Diseases
Tags: Rare disease
Lead Inventor: Michael Palladino
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Gregg E. Homanics PhD
Michael John Palladino
Date Submitted: 2020-10-21
Collections: Cardiometabolic

Small Molecule Allosteric Modulators of Class B GPCRs in the PTHR and Method to Identify Them

05559

Structure-guided discovery yields four small-molecule negative allosteric modulators of PTHR, offering oral, targeted osteoporosis therapy.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Musculoskeletal
Endocrinology and Metabolic Diseases
Lead Inventor: Ieva Sutkeviciute
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Ivet Bahar
Pemra Doruker
Jiyoung Lee
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2020-11-19
Collections: Cardiometabolic
Women's & Reproductive Health

Novel Method of Single Molecule Analysis

05993

New SMADNE method analyzes single protein-DNA interactions in nuclear extracts using multi-color fluorescence, rapidly revealing binding kinetics.

Technology Type: Life Science Research Tool
Technology Subtype: Nucleic Acid
Lead Inventor: Bennett Van Houten
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: FNU Namrata Kumar
Matthew A. Schaich
Brittani L. Schnable
Date Submitted: 2022-03-26

HIF1 Activators as Therapeutics for Triosephosphate Isomerase Deficiency (TPI Df)

07001

HIF1-activating triazines boost TPI expression, repurposing approved PHD inhibitors (e.g., vadadustat) for TPI deficiency.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Musculoskeletal
Lead Inventor: Michael Palladino
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Michael John Palladino
Andreas Vogt
Date Submitted: 2024-12-09

Nitro-fatty Acids for Treating Aortic Aneurysm

05302

Nitro-oleic acid (nitro-fatty acid) shows promise halting abdominal aortic aneurysm progression via anti-inflammatory effects.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Cardiovascular
Therapeutic Indications: Other
Lead Inventor: Francisco Schopfer
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Yuqing Eugene Chen
Bruce A. Freeman
Francisco Jose Schopfer PhD
Date Submitted: 2020-04-13
Collections: Cardiometabolic

Development of WCRC-25, an Invasive Lobular Carcinoma Cell Line

06163

A new ER-negative invasive lobular carcinoma cell line with CDH1, FOXA1, CTCF, BRCA2, TP53 mutations for drug testing and precision oncology.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Lead Inventor: Steffi Oesterreich
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Adrian Vincent Lee
Steffi Oesterreich
Date Submitted: 2022-09-14
Collections: Women's & Reproductive Health

New Approach to Combat Lithium-Induced Diabetes Insipidus

04699

Nrf2 activation via Bardoxolone methyl offers a novel Li-NDI therapy, reducing polyuria/polydipsia and protecting kidney health.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Nephrology
Endocrinology and Metabolic Diseases
Therapeutic Indications: Chronic Kidney Disease (CKD)
Diabetes
Lead Inventor: Francisco Schopfer
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Soma Jobbagy
Francisco Jose Schopfer PhD
Dario A. Vitturi Iglesias
Date Submitted: 2018-08-02
Collections: Cardiometabolic

MATS Proteomics Test

05511

Hybrid mass-spectrometry + ML platform enabling absolute, high-throughput proteome quantitation for biomarker discovery and clinical diagnostics.

Technology Type: Diagnostic/Assay
Technology Subtype: Biomarker
Lead Inventor: Kunhong Xiao
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Fei Fang
Kunhong Xiao
Date Submitted: 2020-09-24

Models of DNA Mismatch Repair Deficiency (Including Panc02 and 4T1)

05503

CRISPR MLH1 knockout creates MSI murine cancer models to study immunogenicity, apoptosis, and immunotherapy in vivo.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Oncology
Lead Inventor: Lin Zhang
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Jian Yu
Lin Zhang
Date Submitted: 2020-09-11

Superecliptic pHluorin (SEP)-PTH Receptor (SEP-PTHR) Stable Cells

04806

SEP-PTHR stable cells enable real-time, pH-controlled visualization of PTH receptor trafficking, internalization, and recycling.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Lead Inventor: Peter Friedman
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Peter Andrew Friedman
Date Submitted: 2018-11-09

Beta-Catenin Inhibition Therapy for Treating Porphyria

04519

β-catenin–targeted liver therapy broadens porphyria treatment by rebalancing heme synthesis, degradation, and proteostasis.

Technology Type: Therapeutic Modality
Technology Subtype: Gene Therapy - RNA
Therapeutic Areas: Hematology
Tags: Rare disease
Lead Inventor: Satdarshan Monga
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Marc Abrams
Satdarshan Pal Singh Monga
Kari Nichole Nejak-Bowen
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2018-02-15
Collections: Cell & Gene Therapy

Novel Nitro Nitrate Lipid Intermediates that Mediate Nitrosating and Alkylating Reactions

03996

Nitro-nitrate-lipid intermediates act as versatile NO donors, offering vasodilation with dual nitrosating/alkylating actions for CVD therapy.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Cardiovascular
Lead Inventor: Marco Fazzari
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Marco Fazzari
Bruce A. Freeman
Francisco Jose Schopfer PhD
Date Submitted: 2016-07-19
Collections: Cardiometabolic

E-cadherin as a Biomarker of Response to Anti-IGF1R Inhibitors

04468

E-cadherin loss predicts and enhances response to anti-IGF1R therapy, enabling personalized cancer treatment strategies.

Technology Type: Diagnostic/Assay
Technology Subtype: Biomarker
Therapeutic Areas: Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Lead Inventor: Adrian Lee
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Adrian Vincent Lee
Alison Mary Nagle
Steffi Oesterreich
Date Submitted: 2017-12-24
Collections: Women's & Reproductive Health

Therapeutic Targets for TPI Deficiency

05520

Identifies novel regulators of mutant TPI turnover, revealing drug targets to stabilize cytosolic proteins for TPI deficiency.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Hematology
Tags: Rare disease
Lead Inventor: Michael Palladino
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Stacy Lynn Hrizo
Michael John Palladino
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2020-10-05

PUMA Gene and p53 Binding Site Knockout Cell Lines for Cancer Research

02384

PUMA p53 site knockout cell lines enable focused study of PUMA-mediated apoptosis in cancer research, via AAV-targeted deletions.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Oncology
Tags: Immuno-oncology
Drug Discovery - Target
Lead Inventor: Lin Zhang
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Jian Yu
Lin Zhang
Technology Readiness Level: 3. Prototype development
Date Submitted: 2011-01-14

Models of DNA Mismatch Repair Deficiency

05460

CRISPR-induced MLH1 inactivation creates immunogenic, MSI colorectal tumor models to study apoptosis-driven anti-tumor immunity and immunotherapy.

Technology Type: Life Science Research Tool
Technology Subtype: Nucleic Acid
Therapeutic Areas: Immunology
Oncology
Lead Inventor: Lin Zhang
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Jian Yu
Lin Zhang
Date Submitted: 2020-07-28

Genetically Engineered MCF-7 Cells for pin1-driven Breast Cancer Cell Cycle Research

05275

Engineered MCF-7 cells overexpress Pin1 to study breast cancer cell cycle regulation and screen targeted therapies.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Lead Inventor: Shivendra Singh
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Shivendra V. Singh
Date Submitted: 2020-03-11
Collections: Women's & Reproductive Health

Treatment for Pediatric Bronchopulmonary Dysplasia

06694

Oral vamorolone may treat infant bronchopulmonary dysplasia safely, reducing long-term corticosteroid side effects.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Respiratory
Therapeutic Indications: Other
Tags: Pediatrics
Life Science
Lead Inventor: Donald DeFranco
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Timothy Cole
Donald B. DeFranco
Nathalie El Khoury Juri
Date Submitted: 2024-03-19

Cell Surface Expression Enhancing Peptides (CSEEPs)

04785

CSEEPs are short GPCR N-terminus peptides fused to receptors, boosting surface trafficking and high-level expression for research.

Technology Type: Therapeutic Modality
Technology Subtype: Peptide
Lead Inventor: Cheng Zhang
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Heng Liu
Lei Wang
Cheng Zhang
Date Submitted: 2018-10-23

Novel Small Molecule Therapies for Cardiovascular and Metabolic Disorders

03924

8-substituted guanine/guanosine drugs: potassium-sparing diuretics that lower blood pressure, reduce stroke and sickling.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Cardiovascular
Nephrology
Therapeutic Indications: Stroke
Pulmonary arterial hypertension (PAH)
Lead Inventor: Edwin Jackson
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Edwin Kerry Jackson
Technology Readiness Level: 5. Drug candidate created
Date Submitted: 2016-05-04
Collections: Cardiometabolic

Targeting CytB5R3 to Increase Nitric Oxide Signaling

03249

Novel Cyb5R3-targeting compounds modulate NO signaling to reversibly vasodilate or vasoconstrict, enabling dual cardiovascular therapies.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Discovery - Target
Therapeutic Areas: Neuroscience
Cardiovascular
Therapeutic Indications: Migraine
Other
Lead Inventor: Adam Straub
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Adam C. Straub
Date Submitted: 2014-02-19
Collections: Cardiometabolic

Novel Selective NADPH Oxidase 2 Inhibitors

03015

Selective bridged tetrahydroisoquinolines inhibit Nox2, reducing ROS-driven cardiovascular, cancer, and neurological risks with targeted IC50.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Endocrinology and Metabolic Diseases
Neuroscience
Therapeutic Indications: Parkinson's Disease
Other
Alzheimer's Disease
Tags: Aging
Lead Inventor: Patrick Pagano
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Eugenia Eugenia Cifuentes Pagano
Patrick Joseph Pagano
Erin M. Skoda
Date Submitted: 2013-04-02
Collections: Cardiometabolic

Anti-FKBP38 Polyclonal Antibody

03240

FKBP38 polyclonal antibody: highly specific, validated for western blot and immunofluorescence in human/mouse cells, ideal for mTOR and cancer studies.

Technology Type: Life Science Research Tool
Technology Subtype: Protein
Lead Inventor: Yu Jiang
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Yu Jiang
Date Submitted: 2014-02-11

Aerosolized Peptide Inhibitors of NADPH Oxidase for the Treatment of Cardiopulmonary Diseases

02241

Aerosolized Nox2-specific peptide blocks NADPH oxidase, reducing cardiopulmonary disease progression with targeted, enhanced delivery.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Neuroscience
Cardiovascular
Therapeutic Indications: Parkinson's Disease
Alzheimer's Disease
Stroke
Lead Inventor: Patrick Pagano
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Patrick Joseph Pagano
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2010-06-03
Collections: Cardiometabolic

Nitrated-fatty Acids Modulation of Type II Diabetes

01545

Nitrated fatty acids improve type 2 diabetes by PPAR-γ modulation, boosting insulin sensitivity without typical TZD side effects.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Cardiovascular
Endocrinology and Metabolic Diseases
Therapeutic Indications: Diabetes
Lead Inventor: Bruce Freeman
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Bruce A. Freeman
Date Submitted: 2007-08-01
Collections: Cardiometabolic

Cyclic Adenosine Monophosphates for Reducing the Formation of Adhesions

01815

Cyclic adenosine monophosphates reduce post-surgical adhesions using targeted compositions and administration methods.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Gastroenterology
Tags: Surgery
Lead Inventor: Edwin Jackson
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Edwin Kerry Jackson
Date Submitted: 2008-09-01
Collections: Regenerative Medicine
Women's & Reproductive Health

Gastrin-Releasing Peptide Receptor Transgenic Mouse

01176

Generated GRPR-overexpressing mice in airway epithelium reveal altered bronchiolar structure, suggesting GRPR’s role in lung tumorigenesis.

Technology Type: Life Science Research Tool
Technology Subtype: Animal Model
Therapeutic Areas: Oncology
Therapeutic Indications: Lung cancer - other
Lung Cancer - Non-Small Cell
Lead Inventor: Jill Siegfried
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Xuwan Liu
Jill M. Siegfried Ph.D.
Laura Ann Stabile
Date Submitted: 2005-11-18

Utility of Mutant Drosophila to Develop Therapies for Mitochondrial Diseases

01079

Mutant fruit flies reveal a novel ATP6 mitochondrial mutation causing neuromuscular defects, enabling in vivo therapy screening.

Technology Type: Life Science Research Tool
Technology Subtype: Animal Model
Therapeutic Areas: Endocrinology and Metabolic Diseases
Therapeutic Indications: Mitochondrial Disease
Lead Inventor: Michael Palladino
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Alicia M. Celotto
Michael John Palladino
Date Submitted: 2005-03-30
Collections: Cardiometabolic

Acellular Central Nervous System (Spinal Cord)-Derived Product for Tissue Engineering and Regenerative Therapies

01915

Acellular porcine spinal cord scaffold supports neuronal growth; injectable, lyophilizable CNS biomaterial for regenerative therapy.

Technology Type: Therapeutic Modality
Technology Subtype: Protein
Therapeutic Areas: Neuroscience
Tags: Biomaterial
Tissue engineering
Lead Inventor: Alan Boruch
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Alan V. Boruch
Date Submitted: 2009-02-05

Hepatocyte Growth Factor Transgenic Mouse

01177

Transgenic mice overexpressing HGF in lungs accelerate tobacco-induced lung tumorigenesis, modeling aggressive HGF/c-Met–driven adenocarcinoma.

Technology Type: Life Science Research Tool
Technology Subtype: Animal Model
Therapeutic Areas: Oncology
Therapeutic Indications: Lung cancer - other
Lung Cancer - Non-Small Cell
Lead Inventor: Jill Siegfried
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Jill M. Siegfried Ph.D.
Laura Ann Stabile
Date Submitted: 2005-11-18

Breast Cancer Patient Derived Organoids

05679

Patient-derived breast cancer organoids preserving tumor heterogeneity for versatile preclinical testing and personalized therapy.

Technology Type: Life Science Research Tool
Lead Inventor: Adrian Lee
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Adrian Vincent Lee
Date Submitted: 2021-04-28
Collections: Women's & Reproductive Health

Software to Analyze Copy Number Alterations

02147

A novel algorithm creates Virtual Normals to unbiasedly detect copy number alterations with high signal accuracy from test samples.

Technology Type: Life Science Research Tool
Technology Subtype: Bioinformatics
Tags: Genetics
Algorithm
Lead Inventor: Robert Sobol
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Uma R. Chandran
William A. LaFramboise Ph.D.
Aleksandr Lisovich
Date Submitted: 2010-02-17

Peroxisome-Proliferator Activated Receptor-Alpha Agonists for Organ Preservation

01190

PPAR-α agonists, especially gemfibrozil with mannitol, enhance renal preservation and viability in organ perfusion.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Nephrology
Therapeutic Indications: Other
Tags: Drug Repurposing
Lead Inventor: Edwin Jackson
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Travis C. Jackson
Edwin Kerry Jackson
Zaichuan Mi
Date Submitted: 2005-12-16