NAMPT Inhibitors Exhibit Excellent Potency and ADME Properties05522Novel Nampt inhibitors deliver strong potency and favorable ADME, enabling chemotherapy and immune support benefits.Technology TypeTherapeutic ModalityTechnology SubtypeSmall MoleculeTherapeutic AreasImmunologyOncologyTagsAutoimmuneImmuno-oncologyLead InventorBeibei ChenDepartmentMed-MedicineAll Tech InnovatorsBeibei ChenToren FinkelYuan LiuTechnology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2020-10-06
Novel Activators of AMP-activated Protein Kinase03887New nanomolar small molecules block AMPK ubiquitination, stabilizing and activating AMPK to treat metabolic, inflammatory, and cancer disorders.Technology TypeTherapeutic ModalityTechnology SubtypeSmall MoleculeTherapeutic AreasCardiovascularEndocrinology and Metabolic DiseasesTagsAgingLead InventorBeibei ChenDepartmentMed-MedicineAll Tech InnovatorsBeibei ChenYuan LiuRama K. MallampalliTechnology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2016-04-05CollectionsCardiometabolic
New Methodology Increases NAMPT Activity for Treating Several Diseases including Autoimmune Conditions05563New NAMPT-activating compounds boost NAD+ to treat obesity, autoimmune disorders, aging, kidney injury, and cognitive decline.Technology TypeTherapeutic ModalityTechnology SubtypeSmall MoleculeTherapeutic AreasOncologyEndocrinology and Metabolic DiseasesTherapeutic IndicationsObesityLead InventorBeibei ChenDepartmentMed-MedicineAll Tech InnovatorsBeibei ChenToren FinkelYuan LiuTechnology Readiness Level2. Initial proof of concept, in-vitroDate Submitted2020-11-23CollectionsCardiometabolic
300 Novel CB1 Antagonists Hold Potential for new Treatments05523New, structurally distinct CB1 antagonists offer broad potential for metabolic therapies and weight management. 15 words max, 120-150 characters.Technology TypeTherapeutic ModalityTechnology SubtypeSmall MoleculeTherapeutic AreasNeuroscienceEndocrinology and Metabolic DiseasesTherapeutic IndicationsObesityLead InventorBeibei ChenDepartmentMed-MedicineAll Tech InnovatorsBeibei ChenToren FinkelYuan LiuTechnology Readiness Level2. Initial proof of concept, in-vitroDate Submitted2020-10-06CollectionsCardiometabolic
Novel Activators of AMP-activated Protein Kinase05032Novel AMPK activators block ubiquitin-mediated degradation, boosting AMPK levels with nanomolar potency for metabolic, inflammatory, and cancer therapies.Technology TypeTherapeutic ModalityTechnology SubtypeSmall MoleculeTherapeutic AreasOncologyEndocrinology and Metabolic DiseasesTagsAgingLead InventorBeibei ChenDepartmentMed-MedicineAll Tech InnovatorsBeibei ChenToren FinkelYuan LiuTechnology Readiness Level2. Initial proof of concept, in-vitroDate Submitted2019-06-24CollectionsCardiometabolic
Small Molecules Maintaining NMNAT2 Levels Prevent Degradation04729First-in-class compounds preserve NMNAT2 levels, potentially preventing axon degeneration after injury and in neurodegenerative diseases.Technology TypeTherapeutic ModalityTechnology SubtypeSmall MoleculeTherapeutic AreasNeuroscienceLead InventorBeibei ChenDepartmentMed-MedicineAll Tech InnovatorsBeibei ChenToren FinkelYuan LiuTechnology Readiness Level2. Initial proof of concept, in-vitroDate Submitted2018-09-10
Novel Small Molecule FIEL1 Inhibitor in Inflammatory and Fibrotic Lung Injury03443Novel FIEL1 inhibitor reduces inflammation and fibrosis in lung injury models, offering IPF-focused therapeutic potential.Technology TypeTherapeutic ModalityTechnology SubtypeSmall MoleculeTherapeutic AreasRespiratoryTherapeutic IndicationsIdiopathic pulmonary fibrosis (IBF)Lead InventorBeibei ChenDepartmentMed-MedicineAll Tech InnovatorsBeibei ChenDate Submitted2014-11-11
Small-Molecule Stabilizers of TFEB for Local Ocular Delivery in Age-Related Retinal Disease04690Small-molecule GT300 activates TFEB via intravitreal delivery, boosting retinal lysosome autophagy to modulate dry AMD.Technology TypeTherapeutic ModalityTechnology SubtypeSmall MoleculeTherapeutic AreasOphthalmologyTherapeutic IndicationsGlaucomaGeographic atrophyAge-related macular degenerationLead InventorBeibei ChenDepartmentMed-MedicineAll Tech InnovatorsBeibei ChenToren FinkelYuan LiuTechnology Readiness Level4. Pre-clinical developmentDate Submitted2018-07-26
Anti-Inflammatory Small Molecules for Treatment of Chronic Inflammatory Disorders04731New small-molecule NF-κB inhibitors target chronic inflammation (asthma, RA, IBD) and may aid aging and cancer therapy.Technology TypeTherapeutic ModalityTechnology SubtypeSmall MoleculeTherapeutic AreasGastroenterologyRespiratoryTherapeutic IndicationsUlcerative ColitisAsthmaLead InventorBeibei ChenDepartmentMed-MedicineAll Tech InnovatorsBeibei ChenToren FinkelYuan LiuTechnology Readiness Level2. Initial proof of concept, in-vitroDate Submitted2018-09-10
