Therapeutic Indications

Ductal carcinoma (Breast cancer)

Advanced Temporal Breast Tissue Dynamics for Precise Cancer Risk Prediction

07270

A dynamic breast density analysis using velocity and acceleration over time to improve personalized, early cancer risk prediction.

Technology Type: Digital Health
Technology Subtype: Clinical Decision Support
Therapeutic Areas: Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Tags: Machine learning
Platform Technology
Algorithm
Lead Inventor: Ju Hun Lee
Department: Med-Radiology
All Tech Innovators: Andriy Bandos
Ju Hun Lee
Robert Mark Nishikawa
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2025-07-30
Collections: Women's & Reproductive Health

Development of WCRC-25, an Invasive Lobular Carcinoma Cell Line

06163

A new ER-negative invasive lobular carcinoma cell line with CDH1, FOXA1, CTCF, BRCA2, TP53 mutations for drug testing and precision oncology.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Lead Inventor: Steffi Oesterreich
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Adrian Vincent Lee
Steffi Oesterreich
Date Submitted: 2022-09-14
Collections: Women's & Reproductive Health

RNA- and DNA-Based Assays for Predicting Paclitaxel Resistance in Triple Negative Breast Cancer

05224

RNA- and DNA-based assays identify a TNBC-specific fusion linked to paclitaxel resistance, enabling therapy pivots.

Technology Type: Diagnostic/Assay
Technology Subtype: Biomarker
Therapeutic Areas: Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Lead Inventor: Xiaosong Wang
Department: Med-Pathology
All Tech Innovators: Xiaosong Wang
Date Submitted: 2020-01-17
Collections: Women's & Reproductive Health

uPAR-Targeting Human Antibody for Treating Cancer and Fibrotic Diseases

06240

uPAR-targeting human VH antibodies offer potent, versatile cancer and fibrotic-disease therapy with VH-Fc formats.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - mAb
Therapeutic Areas: Hepatology
Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Cirrhosis
Melanoma
Lead Inventor: Dimiter Dimitrov
All Tech Innovators: Xiaojie Chu
Dimiter Stanchev Dimitrov
Wei Li
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2022-12-06
Collections: Cardiometabolic
Women's & Reproductive Health

A Novel Neoplastic Fusion Transcript Predicts Sensitivity to the MEK Inhibitor Trametinib in More Aggressive and Metastatic Breast Cancers

05317

Fusion RAD51AP1-DYRK4 predicts trametinib sensitivity in aggressive/metastatic breast cancers, enabling targeted MEK inhibitor therapy.

Technology Type: Diagnostic/Assay
Technology Subtype: Biomarker
Therapeutic Areas: Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Tags: Precision medicine
Personalized Medicine
Women's Health
Lead Inventor: Xiaosong Wang
Department: Med-Pathology
All Tech Innovators: Chia Chia Liu
Xiaosong Wang
Date Submitted: 2020-04-22
Collections: Women's & Reproductive Health

Personalized Pain Management: Predicting Chronic Pain Post-Mastectomy

02280

Personalized post-mastectomy pain risk profiling using genetic and psychosocial data to tailor perioperative care.

Technology Type: Diagnostic/Assay
Technology Subtype: Biomarker
Therapeutic Areas: Neuroscience
Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Pain
Tags: Genetics
Personalized Medicine
Clinical Decision Support
Lead Inventor: Inna Belfer
Department: GSPH-Human Genetics
All Tech Innovators: Inna Belfer
Feng Dai
Technology Readiness Level: 4. Proof of concept
Date Submitted: 2010-08-22
Collections: Women's & Reproductive Health

E-cadherin as a Biomarker of Response to Anti-IGF1R Inhibitors

04468

E-cadherin loss predicts and enhances response to anti-IGF1R therapy, enabling personalized cancer treatment strategies.

Technology Type: Diagnostic/Assay
Technology Subtype: Biomarker
Therapeutic Areas: Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Lead Inventor: Adrian Lee
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Adrian Vincent Lee
Alison Mary Nagle
Steffi Oesterreich
Date Submitted: 2017-12-24
Collections: Women's & Reproductive Health

Glutaminase Inhibitors

03304

Novel glutaminase inhibitors starve cancer cells of glutamine, showing in vivo tumor suppression and potential TNBC therapy.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Lead Inventor: Lee McDermott
Department: Pharm-Pharmaceutical Science
All Tech Innovators: Prema Chandrasekhar Iyer
Lee Apostle McDermott
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2014-04-29
Collections: Women's & Reproductive Health

Novel Human Antibodies Targeting ENPP1

05859

Novel fully human anti-ENPP1 antibodies offer targeted cancer immunotherapy potential, compatible with BiTE, CAR-T, and ADC strategies.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - mAb
Therapeutic Areas: Immunology
Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Solid tumor
Lung cancer - other
Tags: Immuno-oncology
Lead Inventor: Dimiter Dimitrov
All Tech Innovators: Dusan Baek
Xiaojie Chu
Dimiter Stanchev Dimitrov
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2021-10-30
Collections: Women's & Reproductive Health

Targeting Highly Tumor-specific Long Non-coding RNAs for Cancer Diagnosis, Prognosis, and Therapy

04518

Profile of cancer-linked long non-coding RNAs as biomarkers and therapeutic targets, enabling diagnosis, prognosis, and treatment.

Technology Type: Diagnostic/Assay
Technology Subtype: In vitro Diagnostic
Therapeutic Areas: Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Lead Inventor: Da Yang
Department: Pharm-Pharmaceutical Science
All Tech Innovators: Zehua Wang
Da Yang
Date Submitted: 2018-02-14
Collections: Women's & Reproductive Health

Selective Zero-Quantum Coherence Transfer (Sel-ZQC) for High-Resolution Metabolite Imaging at Ultrahigh Field without Inhomogeneous Line Broadening

02457

Sel-ZQC enables high-resolution metabolite MRI at ultrahigh fields without hardware stabilization, boosting SNR and lipid separation.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Lead Inventor: Qiuhong He
Department: Med-Radiology
All Tech Innovators: Jeffrey W. Barker
Song Chen
Qiuhong He
Date Submitted: 2011-04-08
Collections: Women's & Reproductive Health

Novel Immune-Stimulating Virus for Cancer Therapy

05986

Engineered rrVSV-G selectively targets HER2-positive cancers, boosting immunotherapy with tumor-specific oncolytic viral action.

Technology Type: Therapeutic Modality
Technology Subtype: Oncolytic Virus
Therapeutic Areas: Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Lead Inventor: Ira Bergman
Department: Med-Pediatrics
All Tech Innovators: Ira Bergman
Yanhua Gao
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2022-03-16
Collections: Women's & Reproductive Health

T Cell Receptors Targeting Mutations in RNA Splicing Factors

04989

Engineered TCRs target mutated RNA splicing factors across cancers, offering personalized immunotherapy with no reactivity to normal proteins.

Technology Type: Therapeutic Modality
Technology Subtype: Cell Therapy - T Cell
Therapeutic Areas: Immunology
Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Ocular/ uveal melanoma
Chronic Lymphocytic Leukemia (CLL)
Tags: Immuno-oncology
Lead Inventor: Udai Kammula
Department: Med-Surgery
All Tech Innovators: Chetana Bhaskarla
Udai Shankar Kammula
Ghanshyam Singh Yadav
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2019-05-10
Collections: Cell & Gene Therapy
Women's & Reproductive Health

Genetically Engineered MCF-7 Cells for pin1-driven Breast Cancer Cell Cycle Research

05275

Engineered MCF-7 cells overexpress Pin1 to study breast cancer cell cycle regulation and screen targeted therapies.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Lead Inventor: Shivendra Singh
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Shivendra V. Singh
Date Submitted: 2020-03-11
Collections: Women's & Reproductive Health

Fully Human FAbs to IGF-1 and IGF-2

04929

Fully human IGF-1/IGF-2–binding Fabs block IGF signaling to curb cancer cell growth, offering novel therapeutics.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - Fab
Therapeutic Areas: Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Prostate cancer / adenocarcinoma
Colorectal cancer (CRC)
Lead Inventor: Dimiter Dimitrov
All Tech Innovators: Dusan Baek
Dimiter Stanchev Dimitrov
John W. Mellors
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2019-03-24
Collections: Women's & Reproductive Health

Antibody Domains that bind to Neutrophil Elastase (NE) polypeptides

05643

Antibody domains targeting neutrophil elastase inhibit its activity, offering cancer and inflammatory disease therapy with ADC potential.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - mAb
Therapeutic Areas: Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Lung cancer - other
Lead Inventor: Dimiter Dimitrov
All Tech Innovators: Dusan Baek
Xiaojie Chu
Dimiter Stanchev Dimitrov
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2021-03-17
Collections: Women's & Reproductive Health

Combined Structural and Chemical Imaging for Breast Cancer Diagnosis

01543

Integrated MRI-MRSI breast detector boosts cancer specificity/sensitivity without radiation, profiling biomarkers like PUFA, lactate, choline.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Reproductive Health
Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Lead Inventor: Qiuhong He
Department: Med-Radiology
All Tech Innovators: Brendan Patrick Clifford
Doudou Gao
Qiuhong He
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2007-07-25
Collections: Women's & Reproductive Health

Multinuclear-selective MR Spectroscopy Imaging Platform for Single-scan Lipid/water Suppression and Metabolite Mapping

01965

Simultaneous lipid/water suppression and multi-metabolite mapping in a single scan using selective multiple-quantum coherence MRI spectroscopy.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Lead Inventor: Qiuhong He
Department: Med-Radiology
All Tech Innovators: Qiuhong He
Date Submitted: 2009-03-26
Collections: Women's & Reproductive Health

Immortalized Breast Cancer Stem Cell Lines for Continuous Self-renewal and Targeted Drug Screening

01687

Reproducible, GFP-labeled breast cancer stem cells maintained by promoter-driven self-renewal enable scalable, targeted drug screening.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Lead Inventor: Edward Prochownik
Department: Med-Pediatrics
All Tech Innovators: Edward V. Prochownik MD, PhD
Date Submitted: 2008-04-04
Collections: Women's & Reproductive Health

Putative Cancer Stem Cells (CSCs) from Mouse Mammary Tumor

02465

Isolation of putative mouse mammary cancer stem cells via retinol signaling to reveal stemness; potential for translational oncology research.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Tags: Women's Health
Lead Inventor: Jaspal Khillan
Department: Med-Immunology
All Tech Innovators: Jaspal S. Khillan
Qingde Wang
Date Submitted: 2011-04-19
Collections: Women's & Reproductive Health

DNA Variants in Personalized Cancer Therapy

03411

Personalized cancer therapy via PARP1 gene variants predicts chemo sensitivity/resistance, guiding PARP inhibitor use across cancers.

Technology Type: Diagnostic/Assay
Technology Subtype: Biomarker
Therapeutic Areas: Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Lung cancer - other
Lead Inventor: Hussein Tawbi
Department: Med-Medicine
All Tech Innovators: Irina Abecassis
Panagiotis Benos
Petr Pancoska
Date Submitted: 2014-09-23
Collections: Women's & Reproductive Health