Therapeutic Indications

Pain

Innovative Low-Profile Deployable and Retrievable Epidural Lead Array System for Pain Management

06614

Ultra-thin, deployable epidural lead array enables safer, retrievable spinal cord stimulation with larger contact area for pain.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Neuroscience
Therapeutic Indications: Pain
Lead Inventor: Trent Emerick
Department: Med-Anesthesiology and Perioperative Medicine
All Tech Innovators: Hassan Beheshti Seresht
Gaurav Chauhan
Youngjae Jae Chun
Date Submitted: 2024-01-17

Magneto-Vibrational Therapy for Phantom Limb Pain

07142

Non-invasive magnetically driven vibration therapy for phantom limb pain, compatible with prosthetic sockets; adjustable, patent-pending.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Therapeutic Areas: Neuroscience
Therapeutic Indications: Pain
Tags: Prosthetics
Lead Inventor: Goeran Fiedler
Department: SHRS-Rehab Sci & Tech
All Tech Innovators: Aiden Chinwalla
Goeran Fiedler
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2025-04-07

Novel Treatment for Phantom Limb Pain

05033

Vibration-enabled prosthetic liners deliver non-invasive phantom limb pain relief, controlled via wireless vibro-motors for home use.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Therapeutic Areas: Neuroscience
Therapeutic Indications: Pain
Tags: Prosthetics
Lead Inventor: Brianna Perry
Department: SHRS-Rehab Sci & Tech
All Tech Innovators: Goeran Fiedler
Brianna Perry
Kevin Charles Quinn
Date Submitted: 2019-06-24

Method for Monitoring Tissue Parameter by Magnetic Resonance Imaging

03250

Spin-lock MRI isolates chemical-exchange signals to quantify proteoglycan content linearly, robust to T1/T2 variations, aiding tissue health assessment.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Neuroscience
Musculoskeletal
Therapeutic Indications: Pain
Osteoporosis
Lead Inventor: Wen Ling
Department: Med-Radiology
All Tech Innovators: Kyong Tae Bae
Tao Jin
Wen Ling
Date Submitted: 2014-02-19
Collections: Women's & Reproductive Health

Personalized Pain Management: Predicting Chronic Pain Post-Mastectomy

02280

Personalized post-mastectomy pain risk profiling using genetic and psychosocial data to tailor perioperative care.

Technology Type: Diagnostic/Assay
Technology Subtype: Biomarker
Therapeutic Areas: Neuroscience
Oncology
Therapeutic Indications: Pain
Ductal carcinoma (Breast cancer)
Tags: Genetics
Personalized Medicine
Clinical Decision Support
Lead Inventor: Inna Belfer
Department: GSPH-Human Genetics
All Tech Innovators: Inna Belfer
Feng Dai
Technology Readiness Level: 4. Proof of concept
Date Submitted: 2010-08-22
Collections: Women's & Reproductive Health

Caudal Epidural Catheter Simulator

06113

Ultrasound-compatible pediatric sacral spine simulator for realistic caudal epidural needle and catheter training, reducing placement errors.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Neuroscience
Therapeutic Indications: Pain
Tags: Pediatrics
Education Technology
Surgery
Lead Inventor: Mihaela Visoiu
Department: Med-Anesthesiology and Perioperative Medicine
All Tech Innovators: Brandon Joseph Barber
Mihaela Visoiu
Daniel Arthur Yates
Date Submitted: 2022-07-27

Smart MRI: New methodology provides MRI results 6 Times Faster Than Current Exams for Adult and Pediatric Populations

04962

Ultra-fast MRI method speeds brain exams 6x+, cutting scans to under 10 minutes and reducing need for pediatric sedation.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Pediatrics/Neonatology
Neuroscience
Therapeutic Indications: Pain
Tags: Pediatrics
Lead Inventor: Vanessa Schmithorst
Department: Med-Radiology
All Tech Innovators: Vanessa Jean Schmithorst
Technology Readiness Level: 3. Prototype development
Date Submitted: 2019-04-17

Targeted Gene Therapies for Pain and Neuro-Related Disorders

04191

Precise neuron-targeted gene therapy blocks chronic pain signaling long-lastingly, offering opioid-sparing relief with minimally disruptive safety.

Technology Type: Therapeutic Modality
Technology Subtype: Gene Therapy - AAV
Therapeutic Areas: Neuroscience
Therapeutic Indications: Pain
Lead Inventor: Rebecca Seal
Department: Med-Neurobiology
All Tech Innovators: Rebecca Pauline Seal
Date Submitted: 2017-03-15
Collections: Cell & Gene Therapy

Novel Therapeutic Approach to Pain and Inflammation

03491

Computationally models hTRPV1 to discover antagonists, enabling targeted pain and inflammation therapies via in silico screening.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Neuroscience
Therapeutic Indications: Pain
Lead Inventor: Xiangqun Xie
Department: Pharm-Pharmaceutical Science
All Tech Innovators: Zhiwei Feng
Xiangqun Xie
Date Submitted: 2015-01-15

A Pain-enabled in vitro System for Studying Pain Mechanisms and Developing Treatments

05994

Pain-enabled human joint chip models OA pain using innervated synovium for mechanism study and drug screening.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Musculoskeletal
Neuroscience
Therapeutic Indications: Pain
Osteoarthritis
Lead Inventor: Hang Lin
Department: Med-Orthopedic Surgery
All Tech Innovators: Michael S. Gold
Hang Lin
Rocky Sung Chi Tuan
Date Submitted: 2022-03-28

CRISPR Epigenetic Therapeutics for Pain Management

05378

CRISPR-based epigenetic modulation via HSV delivery targets pain genes, offering durable, non-DNA-changing pain relief therapies.

Technology Type: Therapeutic Modality
Technology Subtype: Gene Therapy - CRISPR
Therapeutic Areas: Musculoskeletal
Neuroscience
Therapeutic Indications: Pain
Tags: Human performance
Sports medicine
Lead Inventor: Samira Kiani
Department: Med-Pathology
All Tech Innovators: Mo Reza Ebrahimkhani
Samira Kiani
Date Submitted: 2020-05-26
Collections: Cell & Gene Therapy

Novel Targeted Gene-Therapy for Neuropathic Pain

01462

HSV-delivered GlyR α1 gene silences peripheral neurons; glycine activates to relieve chronic neuropathic pain, potentially non-addictive.

Technology Type: Therapeutic Modality
Technology Subtype: Gene Therapy - Vaccinia
Therapeutic Areas: Neuroscience
Therapeutic Indications: Pain
Lead Inventor: Michael Cascio
Department: Med-Microbiology and Molecular Genetics
All Tech Innovators: Michael Cascio
Joseph C. Glorioso III
James R. Goss
Date Submitted: 2007-03-19
Collections: Cell & Gene Therapy

A Mouse Model of Chronic Inflammatory Pain with Co-Morbid Depression and Anxiety

04436

Integrated mouse model links chronic inflammatory pain with depression/anxiety, enabling sex-specific, bidirectional pain-mood mechanism studies.

Technology Type: Life Science Research Tool
Technology Subtype: Animal Model
Therapeutic Areas: Mental and Behavioral Health
Neuroscience
Therapeutic Indications: Pain
Depression
Anxiety
Lead Inventor: Marianne Seney
Department: Med-Psychiatry
All Tech Innovators: Andrea G. Gillman
Marianne Louise Seney
Ajay D. Wasan
Date Submitted: 2017-11-15

Engineered Receptors as Therapeutic Targets

02884

Engineered chloride channel receptors target peripheral pain via gene delivery, offering pH- or drug-activated analgesia.

Technology Type: Therapeutic Modality
Technology Subtype: Protein
Therapeutic Areas: Respiratory
Neuroscience
Therapeutic Indications: Pain
Asthma
Lead Inventor: Yan Xu
Department: Med-Anesthesiology and Perioperative Medicine
All Tech Innovators: Pei Tang
Tommy Stevens Tillman
Yan Xu
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2012-08-31

Gene Therapy for Management of Chronic Pain

03200

HSV-vector gene therapy targets TRPV1/TRPTV1 to alleviate chronic pain, offering a potentially safer, long-lasting analgesic approach.

Technology Type: Therapeutic Modality
Technology Subtype: Other Therapeutic Modality
Therapeutic Areas: Musculoskeletal
Neuroscience
Therapeutic Indications: Pain
Other
Lead Inventor: William Goins
Department: Med-Microbiology and Molecular Genetics
All Tech Innovators: Justus Bernard Cohen
Joseph C. Glorioso III
William F. Goins Ph.D.
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2013-12-13

An In-Home System for Management of Lower Back Pain

05573

Wearable system for real-time back pain Monitoring and telehealth rehab, enabling personalized, home-based kinematic assessment.

Technology Type: Digital Health
Technology Subtype: Healthcare Delivery
Therapeutic Areas: Musculoskeletal
Neuroscience
Therapeutic Indications: Pain
Lead Inventor: Kevin Bell
Department: Bioengineering
All Tech Innovators: Zakiy Firdaus Alfikri
Kevin Michael Bell
William W. Clark
Date Submitted: 2020-12-11