Therapeutic Indications

Parkinson's Disease

Bait Oligonucleotides to Prevent TDP-43 Associated Neurodegeneration

06987

Dual-acting RNA chaperones (24–48 nt) prevent and dissolve TDP-43/FUS aggregates, restoring function and reducing neurodegeneration.

Technology Type: Therapeutic Modality
Technology Subtype: Gene Therapy - RNA
Therapeutic Areas: Neuroscience
Therapeutic Indications: Parkinson's Disease
Amyotrophic lateral sclerosis (ALS)
Alzheimer's Disease
Lead Inventor: Christopher Donnelly
Department: Med-Neurobiology
All Tech Innovators: Christopher James Donnelly
James Shorter
Technology Readiness Level: 5. Drug candidate created
Date Submitted: 2024-11-30
Collections: Cell & Gene Therapy

Integrated 3D Brain Organoids for Modeling the Blood-Brain Barrier and Neurological Disease Mechanisms

06972

Integrated 3D brain organoids recreate the blood-brain barrier for long-term neurodegenerative/viral research and safer drug screening.

Technology Type: Life Science Research Tool
Technology Subtype: Cell Line
Therapeutic Areas: Neuroscience
Therapeutic Indications: Parkinson's Disease
Alzheimer's Disease
Lead Inventor: Velpandi Ayyavoo
Department: GSPH-Infectious Diseases & Microbiology
All Tech Innovators: Velpandi Ayyavoo
Roberta Souza Dos Reis
Sathish Selvam
Date Submitted: 2024-11-12

Novel Treatment for Retinitis Pigmentosa

06383

Pyrvinium targets NS LLPS to restore proteostasis, preserve retinal structure, and may treat retinitis pigmentosa and proteinopathies.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Neuroscience
Ophthalmology
Therapeutic Indications: Parkinson's Disease
Alzheimer's Disease
Retinitis pigmentosa (RP)
Tags: Life Science
Lead Inventor: Bokai Zhu
Department: Med-Medicine
All Tech Innovators: Yuanyuan Chen
William A. Dion
Bokai Zhu
Date Submitted: 2023-04-23

TDP-43 Targeting Antibodies for Diagnosing Neurodegenerative Diseases

07105

Antibody-based TDP-43 detection enables early, non-invasive diagnosis of AD, ALS, PD, and related neurodegenerative diseases.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - mAb
Therapeutic Areas: Neuroscience
Therapeutic Indications: Parkinson's Disease
Amyotrophic lateral sclerosis (ALS)
Alzheimer's Disease
Tags: In Vitro Diagnostic
Lead Inventor: Thomas Karikari
Department: Med-Psychiatry
All Tech Innovators: Thomas K. Karikari
Xuemei Zeng
Date Submitted: 2025-03-04

A Generalizable Brain-Computer Interface for Motor Function Restoration

05806

A versatile, calibration-free brain-computer interface enabling natural, rapid motor restoration across stroke, amputation, and injury.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Musculoskeletal
Neuroscience
Therapeutic Indications: Parkinson's Disease
Other
Lead Inventor: Sudarshan Sekhar
Department: Bioengineering
All Tech Innovators: Aaron P. Batista
Patrick J. Loughlin
Sudarshan Sekhar
Technology Readiness Level: 3. Prototype development
Date Submitted: 2021-09-09

A Novel Customizable Implantable Cranial Device

05740

A sub-scalp, flexible brain–computer implant with wireless control, EEG monitoring, and medication reservoir for enhanced DBS.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Cardiovascular
Neuroscience
Therapeutic Indications: Parkinson's Disease
Multiple Sclerosis (MS)
Stroke
Tags: Brain-computer interface
Lead Inventor: Joseph Rubin
Department: Med-Plastic Surgery
All Tech Innovators: Joseph Peter Rubin
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2021-06-24
Collections: Cardiometabolic

New Biometric Coating for Neural Implants Improves Outcomes

03008

A neural implant coating using the L1 neural adhesion molecule boosts recording quality and longevity, reducing tissue reaction.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Neuroscience
Therapeutic Indications: Parkinson's Disease
Epilepsy
Tags: Coating
Regenerative medicine
Tissue engineering
Lead Inventor: Xinyan Cui
Department: Bioengineering
All Tech Innovators: Erdrin Azemi
Xinyan Cui
Carl F. Lagenaur
Date Submitted: 2013-03-28

Targeted Nanoparticle Therapy for Brain Repair: Harnessing Memory T Cells for Endogenous Neuroregeneration and Neuroimmune Homeostasis

07316

Targeted brain nanoparticles reprogram memory T cells to foster neuroprotection, reduce neuroinflammation, and promote endogenous CNS repair.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Discovery - Target
Therapeutic Areas: Neuroscience
Therapeutic Indications: Parkinson's Disease
Multiple Sclerosis (MS)
Alzheimer's Disease
Tags: Autoimmune
Biomaterial
Polymer
Lead Inventor: Swaminathan Iyer
Department: Med-Pathology
All Tech Innovators: Swaminathan Smita Iyer
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2025-08-29
Collections: Regenerative Medicine

Epidural Spinal Cord Stimulation System for Improving Neurodegenerative Motor Functions

06717

Indirect sensory-nerve stimulation via epidural spinal cord system may improve breathing, speech, and swallowing in neurodegenerative disease.

Technology Type: Medical Device
Technology Subtype: Therapeutic Medical Device
Therapeutic Areas: Respiratory
Neuroscience
Therapeutic Indications: Parkinson's Disease
Spinal muscular atrophy (SMA)
Multiple Sclerosis (MS)
Lead Inventor: Daryl Fields
Department: Med-Surgery
All Tech Innovators: Daryl Fields
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2024-04-15

Novel Selective NADPH Oxidase 2 Inhibitors

03015

Selective bridged tetrahydroisoquinolines inhibit Nox2, reducing ROS-driven cardiovascular, cancer, and neurological risks with targeted IC50.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Endocrinology and Metabolic Diseases
Neuroscience
Therapeutic Indications: Parkinson's Disease
Other
Alzheimer's Disease
Tags: Aging
Lead Inventor: Patrick Pagano
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Eugenia Eugenia Cifuentes Pagano
Patrick Joseph Pagano
Erin M. Skoda
Date Submitted: 2013-04-02
Collections: Cardiometabolic

Stroke treatment using designer secretomes

04846

Designer secretomes from young brains boost aged brain recovery after stroke by replacing downregulated immune and repair factors.

Technology Type: Therapeutic Modality
Technology Subtype: Protein
Therapeutic Areas: Neuroscience
Cardiovascular
Therapeutic Indications: Parkinson's Disease
Other
Alzheimer's Disease
Tags: Aging
Lead Inventor: Jun Chen
Department: Med-Neurology
All Tech Innovators: Jun Chen
Xiaoming Hu
Lawrence Richard Wechsler
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2019-01-02
Collections: Cardiometabolic

Aerosolized Peptide Inhibitors of NADPH Oxidase for the Treatment of Cardiopulmonary Diseases

02241

Aerosolized Nox2-specific peptide blocks NADPH oxidase, reducing cardiopulmonary disease progression with targeted, enhanced delivery.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Neuroscience
Cardiovascular
Therapeutic Indications: Parkinson's Disease
Alzheimer's Disease
Stroke
Lead Inventor: Patrick Pagano
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Patrick Joseph Pagano
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2010-06-03
Collections: Cardiometabolic

Novel Treatment for Neurodegenerative Diseases Associated with Protein Polymerization

02252

FDA-approved therapies promote autophagy to clear protein aggregates in neurodegenerative models, potentially delaying disease progression.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Neuroscience
Therapeutic Indications: Parkinson's Disease
Huntington's Disease
Alzheimer's Disease
Tags: Drug Repurposing
Lead Inventor: David Perlmutter
Department: School of Medicine
All Tech Innovators: Stephen Chongoh Pak
David Hirsch Perlmutter MD
Gary A. Silverman
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2010-06-21

Innovative Short-T2 Sodium MRI for Accurate Intracellular Sodium Measurement

03055

Short-T2 sodium MRI enables noninvasive intracellular Na+ measurement with lower SAR, higher SNR, aiding brain tumor and neurological disease assessment.

Technology Type: Medical Device
Technology Subtype: Diagnostic Imaging
Therapeutic Areas: Neuroscience
Oncology
Therapeutic Indications: Parkinson's Disease
Multiple Sclerosis (MS)
Epilepsy
Lead Inventor: Yongxian Qian
Department: Med-Radiology
All Tech Innovators: James Michael Mountz
Ashok Panigrahy
Yongxian Qian
Date Submitted: 2013-05-15

Stapled Acid-Sensitive Endosome Disrupting Alginates

03618

Acid-responsive alginoketal nanoparticles release divalent cations and cargo in acidic endosomes, enabling targeted cancer and biofilm therapies.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Neuroscience
Oncology
Therapeutic Indications: Parkinson's Disease
Alzheimer's Disease
Solid tumor
Lead Inventor: Abhinav Acharya
Department: Chem/Petroleum Engineering
All Tech Innovators: Abhinav Prakash Acharya
Steven R. Little
Date Submitted: 2015-05-21

Novel Calcium Channel Agonist to Treat Lambert Easton

02841

A novel, use-dependent calcium channel agonist GV-58 shows promise for Lambert-Eaton syndrome, boosting neurotransmitter release with fewer side effects.

Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Neuroscience
Therapeutic Indications: Parkinson's Disease
Amyotrophic lateral sclerosis (ALS)
Lead Inventor: Peter Wipf
Department: Chemistry
All Tech Innovators: Mary Liang
Stephen D. Meriney
Peter Wipf
Date Submitted: 2012-07-23

Anti-Human and Mouse PTEN-Induced Kinase-1 (PINK1) Polyclonal Antibodies

01873

Antibody tooling targeting human/mouse PINK1 kinase loop to study mitophagy and Parkinson-related pathology.

Technology Type: Life Science Research Tool
Technology Subtype: Protein
Therapeutic Areas: Neuroscience
Therapeutic Indications: Parkinson's Disease
Lead Inventor: Charleen Chu
Department: Med-Pathology
All Tech Innovators: Charleen T. Chu
Date Submitted: 2008-11-20