A Biodegradable, Porous, Thermally Responsive Injectable Hydrogel as Soft Tissue Defect Filler
A novel injectable hydrogel system is designed for soft tissue repair and reconstruction. It features a biodegradable, thermally responsive polymer synthesized from NIPAAm, VP, and MAPLA in an 80:10:10 ratio, which remains liquid at low temperatures and rapidly gels at 37°C. The formulation incorporates extracellular matrix material extracted from decellularized porcine bladder, maintaining bioactive cues that promote healing. Additionally, biocompatible mannitol particles function as porogens, dissolving after injection to form a porous structure ideal for cell infiltration and integration.
Description
This technology is distinguished by its multi-component approach that combines rapid in situ gelation with controlled, temporary porosity and balanced degradation. The reverse-gelling polymer enables minimally invasive delivery and immediate shape conformation, while the ECM enhances the natural regenerative response. The strategic use of transient porogens ensures a well-organized pore network, facilitating vascularization and improved cellular migration. Extensive in vivo evaluations have confirmed its capacity to drive favorable tissue regeneration, positioning it as a transformative approach in regenerative medicine.Applications
- Injectable soft tissue repair- Adipose tissue regeneration scaffold
- Minimally invasive reconstruction
- Regenerative wound healing implant
Advantages
- Minimally invasive injectable delivery for easy application.- Rapid in situ gelation at body temperature, enabling immediate scaffold formation.
- Controlled porous architecture from mannitol porogens that enhances cell infiltration and tissue integration.
- Enhanced healing response through the inclusion of bioactive ECM material.
- Multiple degradation mechanisms that allow for optimal tissue remodeling and absorption.
- Mechanical properties tailored to mimic natural soft tissue, supporting functional regeneration.
- Demonstrated efficacy in reducing inflammation and promoting favorable macrophage polarization.