Alginate-based Microparticles for Controlled Chemokine Delivery and Multipotent Stem Cell Recruitment
This technology stands out for its fine-tuned control over chemokine delivery kinetics, enabling clinicians to customize release profiles to match tissue healing timelines. The broad array of dosage forms supports different therapeutic strategies, from intra-articular injections to targeted systemic distribution. Unlike conventional bolus therapies, these particles establish chemokine gradients that harness endogenous MSC homing, reducing reliance on exogenous cell implantation. Their modular design and non-toxic degradation products offer a flexible platform for precision regenerative medicine in chronic inflammatory disorders.
Description
The alginate-based microparticles are engineered carriers of chemokines such as PDGF, CXCL12, and CCL22 for recruiting multipotent stem cells to sites of injury or inflammation. By varying alginate concentration from 1% to 4%, they achieve predictable release profiles—trimodal at 1% and 2%, bimodal at 1.5%, exponential at 3%, and linear at 4%—over periods up to 40 days. These biocompatible microparticles degrade in vitro without MSC cytotoxicity and have been shown in mouse and osteochondral models to promote stem cell migration into cartilage defects. They can be formulated as gels, creams, injectables, liposomal suspensions, or transdermal patches and administered locally or systemically with targeting ligands for personalized treatment of autoimmune conditions and osteoarthritis.Applications
- Osteoarthritis injectable therapy- Autoimmune disease targeted delivery
- Cartilage regeneration scaffolds
- Wound healing chemokine gels
- Transdermal chemokine patches
Advantages
- Tailored chemokine release kinetics (trimodal, bimodal, exponential, or linear) sustained up to 40 days- Predictable delivery profiles by adjusting alginate concentration
- Efficient recruitment of endogenous MSCs to sites of injury or inflammation
- Biodegradable, non-cytotoxic microparticles ensuring biocompatibility
- Versatile formulations and administration routes (injectables, gels, creams, liposomes, transdermal, oral)
- Local and targeted systemic delivery for osteoarthritis and autoimmune diseases
- Personalized therapy leveraging the patient’s own stem cells for tissue repair and regeneration