Melanomas are aggressive, frequently metastatic tumors responsible for roughly 75% of deaths related to skin cancer. Advanced melanoma is generally refractory to available therapies, and a significant portion will develop distant metastases even with early intervention. Given the continually rising incidence of melanoma despite existing preventive measures such as minimizing exposure to sources of ultraviolet radiation, a need remains for more effective preventive measures, especially in individuals at high risk for developing melanoma. Our vaccine, a sulforaphane-based oral formulation, can prevent melanoma in at risk individuals.
Description
Sulforaphane (SFN) is a naturally occurring compound found in vegetables such as broccoli, cabbage, and cauliflower, among many others. SFN is renowned for its anti-cancer properties and is easily isolated from natural sources. Using our identified formulation and dosage, SFN effectively delayed melanoma progression in mice. Additionally, we identified possible biomarkers for the progression of atypical nevi to melanoma.
Applications
· To prevent melanoma progression
· To reduce the progression of atypical nevi into melanoma
· May alter the clinical appearance of atypical nevi, which are non-obligate melanoma precursor lesions and risk markers
Advantages
· May prevent the development and progression of melanoma
· Naturally occurring product with no significant toxicity or side effects
· Delivered orally, and is safe and well tolerated
· Effectiveness is not limited to specific subsets of patients, i.e., those with cancer cells with a specific mutation
Invention Readiness
In vivo data
IP Status
https://patents.google.com/patent/US9393225B2
