Description
Major histocompatibility complex (MHC) is a cell surface molecule that mediates interactions with immune cells thru the presentation of peptides. MHC is dived into three groups; class I, class II, and class III. MHC class I is formed of an α chain which is composed of three domains: α1, α2, α3. β2 microglobulin is a molecule upon which α1 rest upon. The MHC class I molecule is anchored to the cell membrane by the α3 subunit. The peptide binding grove is formed from α1 and α2 heterodimer.The human leukocyte antigen (HLA) is the corresponding name of the major histocompatibility complex (MHC) in humans. HLA molecules are divided into two subgroups; class I and II. HLA class I molecules (A, B, and C) present intracellular peptides to immune cells. Monoclonal antibody NAMB-1 recognizes the β2 microglobulin in HLA -A, -B and –C.IP Status
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