Description
Major histocompatibility complex (MHC) is a cell surface molecule that mediates interactions with immune cells thru the presentation of peptides. MHC is dived into three groups; class I, class II, and class III. MHC class II is formed of two chains, α and β, each having two domains α1 and α2 and β1 and β2. α2 and β2 function as the transmembrane domain, anchoring the MHC molecule to the cell membrane. The peptide binding groove is formed of the heterodimer of α1 and β1.The human leukocyte antigen (HLA) is the corresponding name of the major histocompatibility complex (MHC) in humans. HLA molecules are divided into two subgroups; class I and II. HLA class II molecules (DP, DM, DOA, DOB, DQ, and DR) present extracellular antigens to T-lymphocytes.Monoclonal antibody LGII-612.14 recognizes the beta chains of the HLA -DR, -DQ and -DP.IP Status
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