Description
These new materials (e.g., PEUU-PC) consist of thermoplastic polyurethanes with non-thrombogenic groups along their backbone to provide a clot-resistant surface that also serves as a temporary drug reservoir. The degradable characteristics come from the incorporation of hydrolytically labile bonds along the backbone of the polymer. When coated onto the surface of vascular stents, these materials have the capacity to deliver drugs over several weeks. Although degradable polyurethanes and non-thrombogenic polymers have both been described separately, this is the first class of materials to effectively combine these activities in a coating suitable for medical devices. Incorporation into vascular stents could increase both efficacy and safety long-term by simultaneously preventing restenosis and blood clots.
IP Status
https://patents.google.com/patent/US9808560B2
