Description
Researchers are exploring improved methodology for preparing and synthesizing these compounds and their analogs in easy ways. Additionally, certain synthetic analogs of these natural products have been demonstrated to possess a multi-fold increase in antitumor activity as compared to their natural parent molecule. Researchers at the University of Pittsburgh have synthesized novel analogs of the antitumor compound FR901464 that show much higher antitumor activity with an easier and more efficient means of synthesis. Three of these analogs are very stable and show antiproliferative activity against various cancer cell lines and multidrug-resistant cells in the picomolar range.
IP Status
https://patents.google.com/patent/WO2009031999A1
