This technology utilizes consensus k-means clustering applied to 25 clinical variables collected from pediatric intensive care patients 24 hours following admission. It categorizes patients with sepsis-induced multiple organ failure into four computable groups based on their host-response patterns and clinical outcomes. The process exclusively relies on routine bedside data—eschewing proprietary biomarkers—thus enabling widespread utilization in standard clinical settings. An accompanying online platform facilitates real-time classification of patients, supporting immediate decision-making regarding anti-inflammatory therapies, trial enrollments, and patient stratification for more robust clinical study designs.
Description
What differentiates this approach is its tailored focus on pediatric sepsis, distinct from methods developed for adult patients. By employing accessible bedside data and advanced statistical techniques, the tool offers a non-invasive yet precise method for patient assessment. Its easy-to-use online interface further enhances practical application in busy clinical environments. Avoiding reliance on proprietary biomarkers not only democratizes patient assessment but also promotes transparency and replicability in clinical trial design, ultimately paving the way for more individualized and effective treatment strategies.
Applications
- Real-time sepsis classification
- Clinical trial stratification tool
- Therapeutic decision support
- Pediatric sepsis risk assessment
Advantages
- Enables real-time classification of patients into distinct sepsis phenotypes using readily available bedside clinical data.
- Supports more precise, personalized treatment decisions by identifying host-response patterns related to clinical outcomes.
- Facilitates improved clinical trial design and patient stratification, potentially leading to clearer, more effective study results.
- Reduces reliance on proprietary biomarkers by using standard, commonly available clinical tests.
- Offers a practical online platform for clinicians, enhancing both research and routine clinical care in pediatric sepsis.
IP Status
Research Tool
