A novel sensor device utilizing size-selective metal-organic framework (MOF) nanostructures integrated with single-walled carbon nanotubes (SWCNTs) offers enhanced sensitivity and selectivity for precise analyte detection in complex samples.
Description
This technology presents an advanced sensor architecture designed to detect specific analytes through a size-selective mechanism enabled by a nanostructured sensor medium. The device comprises a substrate equipped with spaced electrodes upon which a sensor medium is deposited. This sensor medium consists of a composite material combining metal-organic framework (MOF) crystals and single-walled carbon nanotubes (SWCNTs). The MOFs serve as a porous matrix capable of entrapping and adsorbing target molecules based on size-exclusion principles. This selectivity is further refined by a polymer layer—examples include polyvinylidene fluoride (PVDF) and polyether block amide (PEBAX)—which serves as a barrier to ion flux, thereby enhancing the device’s ability to discriminate between analytes of differing molecular dimensions.\r\n\r\nThe integration of SWCNTs within the MOF matrix acts to amplify the sensor’s electrical response owing to their exceptional electrical conductivity and high surface area, facilitating sensitive transduction of chemical interactions into measurable signals. The fabrication process encompasses the synthesis of MOF crystals, their strategic deposition between the electrodes, and the incorporation of SWCNT networks. The polymer layer’s deposition then stabilizes this composite structure, improving robustness and repeatability under varying environmental conditions. The system architecture enables detection of specific chemical species by leveraging the size-selective adsorption properties of MOFs combined with the electrical properties of SWCNTs within a controlled and stabilized polymer matrix.
Applications
- Chemical sensing for identification and quantification of pharmaceuticals and metabolites, including norfentanyl and dopamine, in biomedical and forensic analyses.\r - Environmental monitoring for detection of trace-level pollutants and hazardous chemical species in air, water, and soil samples.\r - Industrial process control where real-time monitoring of specific analytes is critical for safety and quality assurance.\r - Integration into wearable or portable diagnostic devices for rapid point-of-care testing utilizing the sensor’s miniaturized structure and high sensitivity.\r - Research tool for investigating molecular interactions and selective adsorption phenomena via size-exclusion in controlled laboratory settings.
Advantages
- Enhanced Selectivity: The use of MOF crystals with size-exclusion pore dimensions enables precise discrimination of target analytes based on molecular size, reducing interference from non-target species.\r - High Sensitivity: Incorporation of SWCNTs provides efficient electrical signal transduction, allowing detection of low-concentration analytes with rapid response times.\r - Structural Stability: The polymer coating, comprising materials such as PVDF and PEBAX, confers mechanical robustness and inhibition of ion flux, maintaining sensor performance under diverse environmental conditions.\r - Versatile Fabrication: The integration method facilitates customization of sensor properties by selecting different MOFs and polymers, allowing adaptation to various analytes and operational environments.\r - Scalability: The device architecture and manufacturing processes support scalable production, enabling cost-effective deployment in both laboratory and field settings.
Invention Readiness
The sensor technology is currently at an advanced prototype stage where the fundamental materials integration, device assembly, and testing protocols have been established. Experimental data confirm the device’s sensitivity and selectivity across multiple analytes under simulated operational conditions. Future work will focus on optimizing long-term stability, miniaturization for portability, and extensive validation in real-world environments. Additional studies are also planned to expand the range of detectable analytes and refine fabrication parameters for enhanced performance consistency.
IP Status
Patent Pending","tags":["Biomaterial","Platform Technology"],"file_number":"07151","collections":[],"meta_description":"Size-selective MOF-SWCNT sensor boosts targeted analyte detection with polymer-stabilized, scalable, high-sensitivity transduction.","image_url":"","apriori_judge_output":"{\"scores\":{\"novelty\":4.0,\"potential_impact\":4.0,\"readiness\":4.0,\"scalability\":4.0,\"timeliness\":3.0},\"weighted_score\":3.85,\"risks\":[\"TRL 4 (proof of concept) may need remaining integration steps for commercial deployment\",\"Potential manufacturability challenges with MOF-SWCNT integration at scale\",\"Regulatory/compliance considerations for diagnostic/assay applications\",\"Cost of MOF/SWCNT materials and long-term stability in varied sample matrices\"],\"one_sentence_take\":\"High novelty and near-term readiness with strong impact potential, but scale-up and regulatory pathways warrant careful planning.\"}","lead_inventor_name":"Zidao Zeng","lead_inventor_dept":"Chemistry","technology_type":"Diagnostic/Assay","technology_subtype":"In vitro Diagnostic","therapeutic_areas":[],"therapeutic_indications":[],"custom_tags":[],"all_tech_innovators":["Alexander Star","Zidao Zeng"],"date_submitted":"2025-04-15","technology_readiness_level":"4. Proof of concept"},"highlight":{},"matched_queries":null,"score":0.0}