Researchers at the University of Pittsburgh have developed a highly efficient synthesis route for the monomer EDOT-EM, a versatile compound essential for next-generation bioelectronics. This new method significantly reduces the complexity and cost of producing EDOT-EM, making it more accessible for various applications. The monomer can be easily functionalized and electropolymerized, offering vast potential for biomedical and electronic applications.
Description
The invention involves a novel synthesis route for EDOT-EM (3,4-ethylenedioxythiophene with an exomethylene functional group), which is achieved in two steps at room temperature with nearly 100% yield. This method contrasts with the previously published four-step process with low yields. EDOT-EM can be functionalized through thiol-ene click chemistry, allowing attachment of various molecules, from small compounds to large proteins. The monomer can also be electropolymerized into conductive polymers and post-functionalized with biomolecules, enhancing its utility in bioelectronics.
Applications
• Bioelectronics and biomedical devices
• Conductive polymers for electronic applications
• Functionalized materials for research and development
• Drug delivery systems
Advantages
This technology provides a cost-effective and high-yield synthesis route for EDOT-EM, reduces the complexity of production, and allows for versatile functionalization. The ability to easily attach various molecules to EDOT-EM expands its potential applications in bioelectronics and other fields. The high yield and simplicity of the synthesis process make this monomer more accessible for widespread use.
Invention Readiness
The technology is currently at the prototype stage, with successful in vitro demonstrations of the synthesis route and functionalization capabilities. Further development and validation are ongoing to optimize the synthesis process and explore additional applications.
IP Status
https://patents.google.com/patent/US11180507B2
