University of Pittsburgh researchers have developed a novel approach to periodontal treatment using magnesium (Mg) as an anti-inflammatory and immunomodulatory agent. Magnesium deficiency is known to cause a dysregulated immune response and impaired tissue turnover. This invention involves the use of Mg metal nanopowder encapsulated in PLGA microparticles and fibers, which have shown promising results in animal models for treating periodontal disease and regenerating bone by modulating the immune response.
Description
Magnesium has been identified as a crucial cation for its anti-inflammatory and immunomodulatory properties. Researchers have successfully manufactured Mg metal nanopowder in PLGA microparticles and fibers. These Mg-PLGA formulations were tested in murine models of ligature-induced periodontitis and rat calvaria critical size defects. The in vivo data demonstrated significant potential for Mg-PLGA microparticles as a therapy for periodontal disease and for Mg-PLGA fibers in bone regeneration by creating an anti-inflammatory environment that supports tissue regeneration.
Applications
• Periodontal disease treatment
• Bone regeneration
• Immunomodulatory therapies
Advantages
This technology leverages the anti-inflammatory and immunomodulatory properties of magnesium to create an environment conducive to tissue regeneration. The innovative encapsulation of Mg metal into PLGA microparticles and fibers took four years to develop, ensuring a stable and effective formulation. The ability of Mg to polarize macrophages to an M2-like phenotype further enhances its therapeutic potential, making it a promising candidate for treating periodontal disease and promoting bone regeneration.
Invention Readiness
The invention is currently supported by in vivo data demonstrating the efficacy of Mg-PLGA formulations in animal models. The murine ligature-induced periodontitis model showed great results for periodontal treatment, while the rat calvaria critical size defect model indicated promising bone regeneration capabilities.
IP Status
https://patents.google.com/patent/WO2025024551A2
