Innovative Magnesium-Based Therapy for Periodontal Disease
University of Pittsburgh researchers have developed a novel approach to periodontal treatment using magnesium (Mg) as an anti-inflammatory and immunomodulatory agent. Magnesium deficiency is known to cause a dysregulated immune response and impaired tissue turnover. This invention involves the use of Mg metal nanopowder encapsulated in PLGA microparticles and fibers, which have shown promising results in animal models for treating periodontal disease and regenerating bone by modulating the immune response.
Description
Magnesium has been identified as a crucial cation for its anti-inflammatory and immunomodulatory properties. Researchers have successfully manufactured Mg metal nanopowder in PLGA microparticles and fibers. These Mg-PLGA formulations were tested in murine models of ligature-induced periodontitis and rat calvaria critical size defects. The in vivo data demonstrated significant potential for Mg-PLGA microparticles as a therapy for periodontal disease and for Mg-PLGA fibers in bone regeneration by creating an anti-inflammatory environment that supports tissue regeneration.Applications
• Periodontal disease treatment• Bone regeneration
• Immunomodulatory therapies