Intracranial or Intrathecal Device for the Targeted Removal of Cell-Free Hemoglobin from Cerebrospinal Fluid, Lymph, and/or Brain Parenchyma

The technology is an intracranial or intrathecal device engineered to remove cell-free hemoglobin and its degradation products—such as heme and iron—from cerebrospinal fluid, lymph, and brain parenchyma following an intracerebral hemorrhage. It is designed to overcome the limitations of conventional extraventricular drains, which rely on pressure gradients to evacuate fluid. By operating independently of intracranial pressure constraints, it enables continuous and effective clearance of toxic blood components, thereby mitigating neuronal injury and secondary brain damage.

Description

What differentiates this approach is its targeted mechanism for eliminating toxic byproducts that current treatments do not address. Traditional methods work within narrow physiological parameters, often leaving harmful hemoglobin breakdown products behind. In contrast, this technology bypasses those limitations, providing a precise and pressure-independent solution. This capability not only represents a significant advancement in treating hemorrhagic events but also offers the potential for improved patient outcomes by directly addressing a critical unmet need in neurocritical care.

Applications

- ICH treatment device
- CSF detoxification system
- Neurosurgical blood clearance
- Intracranial fluid filtration

Advantages

- Effective removal of neurotoxic hemoglobin, heme, and iron from cerebrospinal fluid and brain tissue.
- Operates independently of intracranial pressure constraints, overcoming limitations of traditional drainage methods.
- Potential reduction of neuronal injury by directly targeting the toxic blood components.
- Addresses an unmet clinical need in the treatment of intracerebral hemorrhage, potentially improving patient outcomes.