This advanced composite structure features highly pure magnesium particles embedded within a biodegradable polymer matrix, such as PLGA, creating a porous scaffold with controllable degradation rates and effective pH buffering. The design allows for precise tuning of mechanical properties and bioactivity, enhancing cell proliferation, angiogenesis, and bone regeneration. Its porous architecture facilitates tissue ingrowth and targeted drug delivery, while compatibility with 3D printing supports the production of patient-specific implants and wound healing devices.
Description
This technology is highly differentiated by its novel combination of materials and the ability to finely adjust the degradation profile through specific polymer and magnesium concentrations. Unlike traditional methods that offer limited control and only short-term pH balancing, this composite sustains a more favorable local environment by buffering acidic byproducts effectively. Moreover, its engineered porosity not only improves mechanical integrity but also promotes extensive vascularization and tissue integration, setting it apart from conventional scaffolds that lack such multifunctionality and customization potential.
Applications
Bone implant devices
3D printed custom implants
Wound healing dressings
Advantages
Tunable degradation rates that allow precise control over scaffold longevity and performance.
Sustained pH buffering to neutralize acidic byproducts, creating a favorable environment for healing.
Enhanced bone regeneration through improved cell proliferation and angiogenesis.
Improved mechanical properties with porous architecture enabling effective tissue ingrowth and drug delivery.
Compatibility with 3D printing techniques for patient-specific implant customization.
IP Status
Abandoned -
https://patents.google.com/patent/US20170014548A1
