{"id":"03691","slug":"method-of-making-trabecular--03691","source":{"id":"03691","dataset":"techtransfer","title":"Method of Making Trabecular Bone in vitro","description_":"<p>As advances in stem cell technology allow us to regenerate and repair some body tissues and organs, bone differentiation remains extremely inefficient. In particular, the ability to create trabecular bone—the porous bone found at the end of long bones, like the femur—has long evaded researchers. Differentiating and regenerating bone tissue from stem cells has a myriad of uses in bone implants for dental work, osteoporosis treatment, and more.</p><p><h2>Description</h2>Using mesenchymal stem cells from mice with a knockout of the chloride-hydrogen exchanger-3 (CLC3) gene, researchers were able to differentiate for osteoblasts in vitro and make trabecular bone with very high efficiency. This is the only cell line that has ever made substrate-independent trabecular bone in vitro, representing an exciting step on the path to efficiently differentiating and generating bone tissue for implants.</p><p><h2>Applications</h2>• Making bone implants\r<br>• Treating osteoporosis\r<br>• Bone grafting for injuries\r<br>• Dental surgery</p><p><h2>Advantages</h2>• Making bone implant</p><p><h2>Invention Readiness</h2>In vitro data</p><p><h2>IP Status</h2><a target=\"_blank\" href=\"https://patents.google.com/patent/US11060060B2\">https://patents.google.com/patent/US11060060B2</a></p><p><h2>Related Publication(s)</h2><p>Larrouture, Q. C., Nelson, D. J., Robinson, L. J., Liu, L., Tourkova, I., Schlesinger, P. H., &amp; Blair, H. C. (2015). Chloride-hydrogen antiporters ClC-3 and ClC-5 drive osteoblast mineralization and regulate fine-structure bone patterning in vitro. Physiological Reports, 3(11), e12607. <a target=\"_blank\" href=\"https://doi.org/10.14814/phy2.12607\">https://doi.org/10.14814/phy2.12607</a></p></p>","tags":["Aging","Biomaterial","Regenerative medicine","Tissue engineering"],"file_number":"03691","collections":[{"key":555,"name":"Women's & Reproductive Health"}],"meta_description":"Efficient in vitro trabecular bone generation from modified mesenchymal stem cells enables implants, osteoporosis treatment, and dental grafts.","image_url":"","apriori_judge_output":"{\"scores\":{\"novelty\":3.0,\"potential_impact\":3.0,\"readiness\":2.0,\"scalability\":3.0,\"timeliness\":1.0},\"weighted_score\":2.7,\"risks\":[\"Age of reference (2015) limits novelty and timeliness\",\"In vitro data stage with regulatory hurdles for clinical-grade products\",\"Requires translation to human cells and GMP/commercial manufacturing\",\"Potential IP/IP landscape unclear\",\"Scalability depends on scalable bioreactor or fabrication for trabecular bone tissue\"],\"one_sentence_take\":\"Moderate novelty with meaningful but dated groundwork; readiness and timeliness are limited by age and translational hurdles, though scalability could be achievable with further development.\"}","lead_inventor_name":"Harry Blair","lead_inventor_dept":"Med-Pathology","technology_type":"Engineering Technology","technology_subtype":"Industrial Biotech","therapeutic_areas":["Musculoskeletal"],"therapeutic_indications":[],"custom_tags":[],"all_tech_innovators":["Harry Colbert Blair","Quitterie Larrouture","Deborah J.  Nelson","Paul Schlesinger","Irina L. Tourkova"],"date_submitted":"2015-07-31"},"highlight":{},"matched_queries":null,"score":0.0}