{"id":"01838","slug":"novel-method-of-idiopathic--01838","source":{"id":"01838","dataset":"techtransfer","title":"Novel Method of Idiopathic Pulmonary Fibrosis (IPF) Detection","description_":"<p><h2>Description</h2>Investigators at the University of Pittsburgh have shown that the activation peptides of Matrix metalloproteases (MMPs) are detectable in the urine via ELISA in mice with lung fibrosis and human patients with IPF but not in the urine of controls. These data suggest that urine detection of MMP activation peptides is feasible and correlates with disease. Because MMP activation contributes to disease initiation and progression, investigators feel that the accurate detection of activation of these proteases will be relevant clinically and may allow for earlier detection of disease as well as allow for prediction of acute exacerbations.</p><p></p><p></p><p></p><p><h2>IP Status</h2><a target=\"_blank\" href=\"https://patents.google.com/patent/US8568996B2\">https://patents.google.com/patent/US8568996B2</a></p><p></p>","tags":[],"file_number":"01838","collections":[],"meta_description":"Urine-based MMP activation peptide detection correlates with IPF, enabling earlier diagnosis and flare prediction via ELISA.","image_url":"","apriori_judge_output":"{\"scores\":{\"novelty\":4.0,\"potential_impact\":4.0,\"readiness\":2.0,\"scalability\":3.0,\"timeliness\":2.0},\"weighted_score\":3.1,\"risks\":[\"Age of technology (2008) may limit novelty after 16+ years\",\"Requires clinical validation across diverse populations\",\"Urine peptide biomarker assays may face regulatory and standardization hurdles\",\"Potential competition from broader IPF biomarkers and imaging approaches\"],\"one_sentence_take\":\"Novel noninvasive urine biomarkers for IPF are promising but conversion to a validated, scalable clinical test faces regulatory and validation hurdles given the technology's age.\"}","lead_inventor_name":"Tim Oury","lead_inventor_dept":"Med-Pathology","technology_type":"Diagnostic/Assay","technology_subtype":"In vitro Diagnostic","therapeutic_areas":["Respiratory"],"therapeutic_indications":["Pulmonary fibrosis"],"custom_tags":[],"all_tech_innovators":["Jan J. Enghild","Naftali Kaminski","Tim David Oury MD, PhD","Laura Marie Voeghtly"],"date_submitted":"2008-09-25"},"highlight":{},"matched_queries":null,"score":0.0}