Novel Regeneration of the Articular Surfaces in the Temporomandibular Joint

This innovation presents a novel approach to treating Temporomandibular Joint Disorder (TMJD).

Description

By combining magnesium with a biodegradable polymer, researchers at the University of Pittsburgh have created a scaffold that promotes bone and cartilage regrowth around the dysfunctional Temporomandibular Joint (TMJ) Disorder. Because the TMJ lacks blood supply, it cannot regenerate on its own. Prior attempts at joint regeneration involve seeding scaffolds with cells to support healing, but we are taking an acellular approach to facilitate rapid clinical translation. Our porous polymer scaffold acts as a substrate to host native regenerative cells — fibrochondrocytes and chondrocytes — that produce collagen and facilitate integration with the surrounding tissue. At the same time, osteoinductive magnesium within the polymer scaffold restores lost bone. Since both magnesium and the polymer material are biodegradable there is no need for a future removal or revision surgery. In goats with an induced TMJ defect, our polymer-magnesium scaffold resulted in new growth of a cartilage layer and a fibrous surface layer, resembling the layers within the healthy joint.

Applications

• Medical Device
• Sports Medicine
• Therapeutic Modality
• Orthopedic Applications

Advantages

This invention offers several advantages over current TMJD treatments. The combination of a biodegradable polymer and magnesium provides a dual approach to regeneration, addressing both bone and cartilage repair. Unlike traditional prosthetics, this scaffold is designed to integrate with the body’s natural tissues, reducing the need for revision surgeries and minimizing the risk of immune responses. Additionally, the acellular approach simplifies the regulatory path, potentially accelerating clinical translation and adoption.

Invention Readiness

The technology is currently at the in vivo testing stage, with promising results observed in animal models. In goats with induced TMJ defects, the polymer-magnesium scaffold facilitated the growth of new cartilage and fibrous tissue, closely resembling the natural joint structure. The next steps include further validation studies, optimization of the scaffold design, and preparation for clinical trials. The invention is supported by a PCT patent application, indicating strong intellectual property protection and commercial potential.

IP Status

https://patents.google.com/patent/US20240277903A1