Peroxisome-Proliferator Activated Receptor-Alpha Agonists for Organ Preservation

Quick Facts:
Reference Number: 01190
Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Nephrology
Therapeutic Indications: Other
Tags: Drug Repurposing
Lead Inventor: Edwin Jackson
Department: Med-Pharmacology and Chemical Biology
All Tech Innovators: Travis C. Jackson, Edwin Kerry Jackson, Zaichuan Mi
Date Submitted: 2005-12-16

Description

When added to an organ preservation solution, Peroxisome Proliferator Activated Receptor-alpha (PPAR-alpha) agonists were observed to improve markers of renal preservation in isolated perfused kidneys whereas perfusion in untreated kidneys caused apoptosis and loss of tissue architecture. The combination of gemfibrozil, a PPAR-alpha agonist, with mannitol, a known organ preserva­tion agent, led to further enhanced renal preserva­tion. Therefore, PPAR-alpha agonists, particularly when combined with mannitol, function as organ preserving drugs and hold potential for improv­ing the viability and function of harvested organs.

IP Status

https://patents.google.com/patent/WO2007106912A2