These superstructures are synthesized using peptide-based methods, specifically through the oxidation of divalent peptide conjugates.
Description
The resulting structures have significant potential applications in areas such as encryption tags, circular polarizers, and chiroptical sensors due to their unique optical properties.
Applications
• Diagnostic Imaging
• Therapeutic Medical Device
• Nanomaterials
• Gene Therapy - CRISPR
Advantages
The single-helical gold nanoparticle superstructures offer several advantages over existing solutions. Firstly, their strong chiroptical activity, which is among the highest reported, makes them ideal for applications requiring precise optical properties. The use of peptide-based assembly methods allows for fine-tuning of the nanoparticle structures, enabling the creation of highly specific and functional materials. Additionally, the ability to control the pitch and density of the helices through chemical modifications provides a versatile platform for developing customized solutions. For example, the introduction of hydrophobic amino acids or the modification of oxidized methionine residues can significantly alter the properties of the superstructures, enhancing their applicability in various fields.
Invention Readiness
The technology is currently at the concept stage, with significant progress made in understanding the molecular basis of the superstructures and their assembly. The invention has undergone rigorous testing and validation, including transmission electron microscopy (TEM), cryogenic electron tomography (cryo-ET), and solid-state nuclear magnetic resonance (ssNMR) spectroscopy. These studies have confirmed the structural parameters and chiroptical properties of the single-helical gold nanoparticle assemblies. The next steps involve further optimization of the synthesis process, scaling up production, and exploring additional applications in collaboration with industry partners.
IP Status
https://patents.google.com/patent/US11389866B2
