As key players in intercellular communication, exosomes play a critical role in many physiological and pathophysiological conditions. Researchers are exploring their use as biomarkers of different diseases and their use as drug carriers in nanomedicine. Making progress in this developing field requires the generation of large numbers of cells in dish-culture, which is prohibitively time consuming. By stimulating the secretion of exosomes by cells, the use of exosomes in nanomedicine can be greatly accelerated.
Description
Researchers identified a potent stimulator of exosome secretion with the ability to enhance exosome production by up to 24-fold. This reagent also increases the amount of circulating exosomes in vivo. This novel method will allow for the rapid production of exosomes for use in drug delivery or other therapeutic applications, as well as providing an ample source for research into exosome-mediated effects and disease biomarkers.
Applications
· Quickly and cost-effectively producing large numbers of exosomes for use in research or nanomedicine
· Enhancing exosome-mediated therapeutic effects
Advantages
· Reduces cost and time needed to generate exosomes
· Can be used in vivo and in vitro
· No other specific treatment for enhancing exosome secretion exists
Invention Readiness
In vivo data
IP Status
https://patents.google.com/patent/US20220280460A1
