Substituted Indoles with Activity to Treat Acute Kidney Injury
Acute kidney injury (AKI) results in long-term reduction in renal function, leading to an increased risk of developing progressive chronic kidney disease (CKD) and end-stage renal disease (ESRD), requiring life-long dialysis. Old age, along with increased prevalence of diabetes, can increase the risk of AKI with CKD, along with individuals in high-risk professions who experience exertional rhabdomyolysis, dehydration, crush injuries, blood loss, burn, and sepsis at higher rates than the general population. No therapies have been proven to reduce AKI-driven, post-injury CKD progression; many experimental drugs given in clinical trials were only effective when given before the initiating injury, and the fact that patients often only seek treatment late in the course of AKI means that effective therapies will need to reverse established injury or rapidly promote repair.
Description
Using a proliferation-based phenotypic assay in zebrafish, researchers have discovered a class of compounds which selectively inhibit HDAC and enhances recovery from acute kidney injury when given days after the initial injury.Applications
· Reducing severity of acute kidney injury· Reducing risk of CKD and ESRD
Advantages
· Can be administered days after initial injury· Reduces risk of developing chronic kidney disease