University of Pittsburgh researchers have developed a novel method for mobilizing hematopoietic progenitor cells using a nucleotide sugar, UDP-Glucose. This method has shown significant potential in improving stem cell yield, particularly in patients who are poor mobilizers. The discovery could revolutionize the fields of stem cell biology and regenerative medicine by providing a more efficient and less toxic alternative to current mobilization techniques.
Description
The present invention relates to the use of uridine diphosphate compounds, particularly UDP-Glucose, in methods for mobilizing hematopoietic progenitor cells from the bone marrow. UDP-Glucose has been shown to effectively mobilize these cells into the peripheral blood, providing a viable alternative to traditional methods such as G-CSF. The combination of UDP-Glucose with other mobilizing agents like G-CSF has demonstrated synergistic effects, enhancing the mobilization efficiency and long-term repopulating potential of the hematopoietic stem cells.
Applications
• Stem cell transplantation
• Hematopoietic stem cell mobilization
• Regenerative medical research
Advantages
• Enhanced Mobilization: UDP-Glucose has been shown to mobilize a significant number of hematopoietic progenitor cells, including long-term repopulating cells.
• Synergistic Effects: When combined with G-CSF, UDP-Glucose enhances the mobilization efficiency, providing a more robust and effective mobilization strategy.
• Reduced Toxicity: As a natural product, UDP-Glucose may mitigate many of the side effects associated with synthetic mobilizers.
• Improved Stem Cell Yield: This method is particularly advantageous for poor mobilizer patients, improving the yield of stem cells for transplantation.
Invention Readiness
The technology has been validated through extensive in vivo studies, demonstrating the efficacy of UDP-Glucose in mobilizing hematopoietic progenitor cells. The combination of UDP-Glucose with G-CSF has shown promising results in enhancing both short-term and long-term repopulating capacities of the mobilized cells.
IP Status
https://patents.google.com/patent/US11173175B2
