{"id":"02655","slug":"validation-of-a-multiplex--02655","source":{"id":"02655","dataset":"techtransfer","title":"Validation of a Multiplex Biomarker Panel for Detection of Abusive Head Trauma in Well-Appearing Children","description_":"<p><h2>Description</h2>Biomarkers for Infant Brain Injury Score (BIBIS) is a rapid multiplex immunoassay of four blood biomarkers coupled with a multivariate algorithm. The BIBIS assay is performed on a proprietary microporous silicon substrate which enables the rapid multiplex analysis of biomarkers from small volumes of biological samples. The resultant biomarker concentrations are processed using a multivariate algorithm to provide a score that is highly predictive of ICH. BIBIS was prospectively tested on 599 patients and demonstrated 89.3% sensitivity and 48.0% specificity for ICH. This technology uniquely enables rapid, automated multiplex biomarker testing, making it conducive for use in acute care settings where rapid diagnosis is important.</p><p></p><p></p><p></p><p><h2>IP Status</h2><a target=\"_blank\" href=\"https://patents.google.com/patent/US20210382073A1\">https://patents.google.com/patent/US20210382073A1</a></p><p></p>","tags":["Pediatrics"],"file_number":"02655","collections":[],"meta_description":"Rapid, automated four-biomarker blood test (BIBIS) with multivariate scoring detects abusive head trauma in children quickly.","image_url":"","apriori_judge_output":"{\"scores\":{\"novelty\":3.0,\"potential_impact\":3.0,\"readiness\":3.0,\"scalability\":2.0,\"timeliness\":1.0},\"weighted_score\":2.9,\"risks\":[\"Outdated reference (2012) may reflect earlier stage; regulatory path uncertain\",\"Limited specificity (48%); potential safety/diagnostic risk\",\"Limited scalability data beyond single-use platform\",\"Market adoption and reimbursement uncertainties\"],\"one_sentence_take\":\"Moderate novelty with a focused pediatric abuse-detection niche, but age of reference, modest specificity, and uncertain regulatory/path-to-market temper overall potential.\"}","lead_inventor_name":"Rachel Berger","lead_inventor_dept":"Med-Pediatrics","technology_type":"Diagnostic/Assay","technology_subtype":"Biomarker","therapeutic_areas":["Intensive Care"],"therapeutic_indications":["Trauma"],"custom_tags":[],"all_tech_innovators":["Rachel Pardes Berger","Patrick M. Kochanek M.D.","Shlomo Ta'asan"],"date_submitted":"2012-01-05"},"highlight":{},"matched_queries":null,"score":0.0}