Delivery of Antagonists and Agonists for Immune Modulation06543Controlled microparticle release delivers ATP antagonists and adenosine receptor agonists to suppress inflammation long-term.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasDermatologyImmunologyTherapeutic IndicationsDermatitisLead InventorElizabeth BentleyDepartmentBioengineeringAll Tech InnovatorsStephen C. BalmertElizabeth BentleyJulie KobyraTechnology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2023-10-17
Accelerated Wound Healing Sustained Release Nanoparticles07150Sustained-release TGF-β3 nanoparticles enhance soft-tissue wound strength, reduce scarring, enabling single-site surgical therapy.TagsImplantable Medical DeviceMaterial ScienceLead InventorThiagarajan MeyyappanDepartmentMed-MedicineAll Tech InnovatorsSteven R. LittleThiagarajan MeyyappanDate Submitted2025-04-15CollectionsRegenerative Medicine
Novel Nutrient Delivery System for Agriculture06559Liposome-based, microfluidic nutrient delivery targets roots, boosting uptake and reducing leaching for sustainable, efficient farming.Technology TypeEngineering TechnologyTechnology SubtypeEnvironmental EngineeringLead InventorAlireza MohammadzadehDepartmentBioengineeringAll Tech InnovatorsLeanne Marie GilbertsonSteven R. LittleAlireza MohammadzadehDate Submitted2023-11-03
Prevention of DED Utilizing a Histone/Protein Deacetylase Inhibitor (HDACi)04403HDAC inhibitor-loaded PLGA microspheres deliver targeted, long-term anti-inflammatory therapy for dry eye by boosting regulatory T cells.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasOphthalmologyTherapeutic IndicationsConjunctivitisDry eye syndromeUveitic macular edema (UME)Lead InventorSteven LittleDepartmentEngr-Dept Chairperson's OfficeAll Tech InnovatorsSteven R. LittleMichelle Lynn RatayTechnology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2017-10-09
A Method to Prepare Patchy Microspheres with Regular Pattern02080Novel method forms regular, patchy microsphere surfaces for masking or functionalization across polymers, minerals, and metals.Technology TypeEngineering TechnologyTechnology SubtypeChemicalTagsPlatform TechnologyLead InventorSteven LittleDepartmentEngr-Dept Chairperson's OfficeAll Tech InnovatorsKaladhar KamalasananSteven R. LittleDate Submitted2009-10-06
iHeart: Injectable Hydrogel for Enhancing or Attracting Regulatory T-Cells06482Injectable hydrogel releases CCL22 to recruit regulatory T cells, reducing reperfusion injury after myocardial infarction.Technology TypeTherapeutic ModalityTechnology SubtypeCell Therapy - T CellTherapeutic AreasCardiovascularTherapeutic IndicationsMyocardial infarctionLead InventorMatthew BorrelliDepartmentChem/Petroleum EngineeringAll Tech InnovatorsMatthew Andrew BorrelliJason BurdickSteven R. LittleTechnology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2023-08-15CollectionsCell & Gene TherapyCardiometabolic
Targeted Treatment of Inflammatory Bowel Disease05417Orally delivered, targeted PLGA microparticles deliver IL-2, TGF-β, and rapamycin to inflamed gut tissue, reducing IBD activity.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasGastroenterologyImmunologyTherapeutic IndicationsChrohn's DiseaseLead InventorRoger SandsDepartmentMed-MedicineAll Tech InnovatorsSteven R. LittleRoger Warren SandsTechnology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2020-06-11
Thermogel-extended Release Microsphere Based Delivery to the Paranasal Sinuses05299Thermogel-PLGA microspheres deliver four-week, localized mometasone furoate to paranasal sinuses post-surgery.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasInfectious DiseaseLead InventorAndrea SchillingDepartmentChemical and Petroleum EngineeringAll Tech InnovatorsStella LeeSteven R. LittleAndrea Leigh SchillingDate Submitted2020-04-10
Controlled Release Microparticle Platform for Localized Prevention of Tissue Calcification and Ossification03248PLGA microparticles deliver BMP receptor inhibitor locally to prevent tissue calcification with sustained, customizable release.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasMusculoskeletalTagsRegenerative medicineSports medicineTissue engineeringLead InventorRiccardo GottardiAll Tech InnovatorsPeter AlexanderPatrick A. BianconiRiccardo Luca GottardiDate Submitted2014-02-17CollectionsRegenerative Medicine
Noninvasive & Long-Acting Thermoresponsive Hydrogel for Sustained Ocular Drug Delivery02867Noninvasive, thermoresponsive ocular gel with drug-loaded microparticles enables month-long, drop-free sustained eye treatment.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasOphthalmologyTherapeutic IndicationsOtherGlaucomaDry eye syndromeLead InventorMorgan DileoDepartmentMed-OphthalmologyAll Tech InnovatorsAnthony CuginiMorgan Virginia DileoSteven R. LittleTechnology Readiness Level4. Pre-clinical developmentDate Submitted2012-08-14
Alginate-based Microparticles for Controlled Chemokine Delivery and Multipotent Stem Cell Recruitment02836Alginate microparticles dose-tune chemokine release (up to 40 days) to recruit endogenous MSCs for targeted regenerative therapies.Technology TypeTherapeutic ModalityTechnology SubtypeCell Therapy - Stem CellLead InventorSteven LittleDepartmentEngr-Dept Chairperson's OfficeAll Tech InnovatorsDaniel A. DesantisRiccardo Luca GottardiMintai HwangDate Submitted2012-07-12CollectionsCell & Gene TherapyRegenerative Medicine
Instrument-Free Assay for In-Clinic Detection of Bladder or Prostate Cancer03825Colorimetric, instrument-free urine test detects bladder/prostate cancer via MMP-2/9–triggered Fe(II) release and Fenton reaction.Technology TypeDiagnostic/AssayTechnology SubtypeOther Diagnostic/AssayTherapeutic AreasOncologyTherapeutic IndicationsProstate cancer / adenocarcinomaLead InventorAbhinav AcharyaDepartmentChem/Petroleum EngineeringAll Tech InnovatorsAbhinav Prakash AcharyaSteven R. LittleTatum Varut TarinDate Submitted2016-02-09
Development of Artificial Stem Cells for Vascular Engineering03799Artificial MSCs: porous microparticles deliver sustained, multi-factor signals for vascular, regenerative therapies without autologous cells.Technology TypeTherapeutic ModalityTechnology SubtypeCell Therapy - Stem CellTherapeutic AreasCardiovascularLead InventorDavid VorpDepartmentBioengineeringAll Tech InnovatorsMorgan Virginia DileoJeffrey T. KrawiecSteven R. LittleDate Submitted2016-01-05CollectionsCell & Gene TherapyCardiometabolic
Targeted Immune Cell Therapy Using CCL22 Muteins for Enhanced Precision06493Precise immune cell targeting via CCL22 muteins and engineered CCR4 receptors, boosting therapy localization and reducing off-target effects.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationLead InventorHeth TurnquistDepartmentMed-SurgeryAll Tech InnovatorsStephen C. BalmertMatthew Andrew BorrelliSteven R. LittleDate Submitted2023-08-24
Thermoresponsive Hydrogel Containing Polymer Microparticles for Controlled Drug Delivery to the Ear03810Single-dose, thermoresponsive ear gel with PLGA microspheres for 14-day ciprofloxacin release and lidocaine.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasOtolaryngologyTagsPolymerPlatform TechnologyLead InventorMorgan DileoDepartmentMed-OphthalmologyAll Tech InnovatorsLiza Anna BrukMorgan Virginia DileoSteven R. LittleDate Submitted2016-01-26
Biomimetic Drug Delivery of an Immunomodulatory Agent for the Treatment of Dry Eye Disease03658Biomimetic, controlled-release immunomodulatory microspheres recruit Tregs to treat inflammatory eye diseases at the source with safer, longer relief.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasOphthalmologyTherapeutic IndicationsDry eye syndromeLead InventorMichelle RatayDepartmentBioengineeringAll Tech InnovatorsStephen C. BalmertMorgan Virginia DileoAndrew Jason GlowackiDate Submitted2015-06-22
Stapled Acid-Sensitive Endosome Disrupting Alginates03618Acid-responsive alginoketal nanoparticles release divalent cations and cargo in acidic endosomes, enabling targeted cancer and biofilm therapies.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasNeuroscienceOncologyTherapeutic IndicationsParkinson's DiseaseAlzheimer's DiseaseSolid tumorLead InventorAbhinav AcharyaDepartmentChem/Petroleum EngineeringAll Tech InnovatorsAbhinav Prakash AcharyaSteven R. LittleDate Submitted2015-05-21
YouBiotics04368Engineered weight-loss probiotic YouBiotics: fat-binding gut bacteria reduce dietary fat absorption, cutting obesity risk affordably.Technology TypeTherapeutic ModalityTechnology SubtypeOther Therapeutic ModalityTherapeutic AreasGastroenterologyEndocrinology and Metabolic DiseasesTherapeutic IndicationsObesityTagsAgingAutoimmuneConsumerLead InventorAbhinav AcharyaDepartmentChem/Petroleum EngineeringAll Tech InnovatorsAbhinav Prakash AcharyaSteven R. LittleTechnology Readiness Level3. Initial proof of concept, in-vivoDate Submitted2017-09-08CollectionsCardiometabolic
Controlled Release Formulations for Induction and Proliferation of Regulatory T Cells02616Controlled release IL-2, TGF-β, and rapamycin formulations induce human regulatory T cells in vitro, enabling targeted in vivo expansion.Technology TypeTherapeutic ModalityTechnology SubtypeCell Therapy - T CellTherapeutic AreasOncologyImmunologyTherapeutic IndicationsSolid tumorLymphomaLeukemiaTagsAutoimmuneImmuno-oncologyLead InventorSteven LittleDepartmentEngr-Dept Chairperson's OfficeAll Tech InnovatorsSiddharth JhunjhunwalaSteven R. LittleGiorgio RaimondiTechnology Readiness Level2. Initial proof of concept, in-vitroDate Submitted2011-11-10CollectionsCell & Gene Therapy
Advanced Pulmonary Treatment with Verteporfin and Glutaminase Inhibitors04344Targeted, controlled lung delivery of Verteporfin with glutaminase inhibitors via porous PLGA particles to treat pulmonary hypertension.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Delivery / FormulationTherapeutic AreasRespiratoryLead InventorAbhinav AcharyaDepartmentChem/Petroleum EngineeringAll Tech InnovatorsAbhinav Prakash AcharyaStephen Yu-Wah Chan MD, PhDAshlee Chennicia GreeneDate Submitted2017-08-07