Lead Inventor

Dimiter Dimitrov

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Fully Human Fabs Binding to the CD94/NKG2A Heterodimer

05650

Fully human antibodies block CD94/NKG2A, restoring NK/T cell activity against cancer and HIV, with strong specificity.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - Fab
Therapeutic Areas: Infectious Disease
Oncology
Therapeutic Indications: HIV
Lung Cancer - Non-Small Cell
Tags: Immuno-oncology
Lead Inventor: Dimiter Dimitrov
All Tech Innovators: Dusan Baek
Dimiter Stanchev Dimitrov
Yae Jin Kim
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2021-03-23
Collections: Women's & Reproductive Health

Fluid Removal Algorithm for Acute Kidney Injury

05831

A standardized, data-driven fluid removal tool for ICU dialysis in AKI, aiming to reduce hypotension and complications.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - scFV
Therapeutic Areas: Oncology
Therapeutic Indications: Solid tumor
Leukemia
Lead Inventor: Dimiter Dimitrov
All Tech Innovators: Dimiter Stanchev Dimitrov
John W. Mellors
Zehua Sun
Date Submitted: 2021-10-06

uPAR-Targeting Human Antibody for Treating Cancer and Fibrotic Diseases

06240

uPAR-targeting human VH antibodies offer potent, versatile cancer and fibrotic-disease therapy with VH-Fc formats.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - mAb
Therapeutic Areas: Hepatology
Oncology
Therapeutic Indications: Cirrhosis
Melanoma
Prostate cancer / adenocarcinoma
Lead Inventor: Dimiter Dimitrov
All Tech Innovators: Xiaojie Chu
Dimiter Stanchev Dimitrov
Wei Li
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2022-12-06
Collections: Cardiometabolic
Women's & Reproductive Health

Human Antibodies Identified as Brain Cancer Immunotherapy Targets

05700

Eight human antibodies target protogenin to curb pediatric medulloblastoma growth, offering promising brain cancer immunotherapy.

Technology Type: Therapeutic Modality
Technology Subtype: Cell Therapy - T Cell
Therapeutic Areas: Oncology
Therapeutic Indications: Diffuse intrinsic pontine gliomas (DIPG)
Medulloblastoma
Brain cancer - Other
Tags: Pediatrics
Rare disease
Lead Inventor: Dimiter Dimitrov
All Tech Innovators: Chuan Chen
Dimiter Stanchev Dimitrov
Wei Li
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2021-05-25
Collections: Cell & Gene Therapy
Rare Diseases

Identification of Fully Human Antibodies

05676

Fully human PSCA-targeting antibodies enable potent ADCC and ADCs against PSCA+ cancers, including prostate tumors.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - Fab
Therapeutic Areas: Oncology
Therapeutic Indications: Prostate cancer / adenocarcinoma
Renal cell carcinoma (RCC)
Pancreatic adenocarcinoma
Lead Inventor: Dimiter Dimitrov
All Tech Innovators: Dusan Baek
Dimiter Stanchev Dimitrov
Dontcho V. Jelev
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2021-04-21

Human Monoclonal Antibodies against SARS-CoV-2

05259

Neutralizing human monoclonal antibodies target SARS-CoV-2 spike RBD, blocking entry or directing infected-cell killing.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - mAb
Therapeutic Areas: Infectious Disease
Therapeutic Indications: Covid-19
Lead Inventor: Dimiter Dimitrov
All Tech Innovators: Chuan Chen
Dimiter Stanchev Dimitrov
Dontcho V. Jelev
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2020-02-26

Fully Human Antibodies Targeting Membrane Proximal Region in Human CEACAM5

05469

Fully human CEACAM5-targeting antibody binds membrane-proximal region with nanomolar affinity, high specificity, and potential NEPC therapy.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - mAb
Therapeutic Areas: Oncology
Therapeutic Indications: Prostate cancer / adenocarcinoma
Tags: Immuno-oncology
Lead Inventor: Dimiter Dimitrov
All Tech Innovators: Dusan Baek
Dimiter Stanchev Dimitrov
John W. Mellors
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2020-08-06

Fully Human Anti-Mesothelin Engineered Antibody VH Domains

05170

Fully human VH-domain CAR-T targets mesothelin tumors; smaller, potentially less immunogenic, improved penetration and cryptic-epitope access.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - scFV
Therapeutic Areas: Oncology
Therapeutic Indications: Pancreatic adenocarcinoma
Ovarian cancer
Mesothelioma
Lead Inventor: Dimiter Dimitrov
All Tech Innovators: Dimiter Stanchev Dimitrov
John W. Mellors
Zehua Sun
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2019-11-15
Collections: Women's & Reproductive Health

Novel Human Antibodies Targeting ENPP1

05859

Novel fully human anti-ENPP1 antibodies offer targeted cancer immunotherapy potential, compatible with BiTE, CAR-T, and ADC strategies.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - mAb
Therapeutic Areas: Immunology
Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Solid tumor
Lung cancer - other
Tags: Immuno-oncology
Lead Inventor: Dimiter Dimitrov
All Tech Innovators: Dusan Baek
Xiaojie Chu
Dimiter Stanchev Dimitrov
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2021-10-30
Collections: Women's & Reproductive Health

PSMA with Multiple Single-Chain and Domain Binders Treats Prostate Cancer

05717

PSMA-targeting VH-domain antibodies enable potent ADCs, ADCC, or CAR-T for prostate cancer with improved penetration.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - mAb
Therapeutic Areas: Oncology
Therapeutic Indications: Prostate cancer / adenocarcinoma
Tags: Immuno-oncology
Lead Inventor: Dimiter Dimitrov
All Tech Innovators: Dimiter Stanchev Dimitrov
Dontcho V. Jelev
Wei Li
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2021-06-09

Human Antibody Domains and Fragments to CD276

04890

Fully human antibody domains and fragments target CD276 (B7-H3) to enhance solid tumor immunotherapy and tumor penetration.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - Bispecific
Therapeutic Areas: Oncology
Therapeutic Indications: Solid tumor
Lead Inventor: Dimiter Dimitrov
All Tech Innovators: Dimiter Stanchev Dimitrov
Wei Li
John W. Mellors
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2019-02-11

Fully Human FAbs to IGF-1 and IGF-2

04929

Fully human IGF-1/IGF-2–binding Fabs block IGF signaling to curb cancer cell growth, offering novel therapeutics.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - Fab
Therapeutic Areas: Oncology
Therapeutic Indications: Prostate cancer / adenocarcinoma
Ductal carcinoma (Breast cancer)
Colorectal cancer (CRC)
Lead Inventor: Dimiter Dimitrov
All Tech Innovators: Dusan Baek
Dimiter Stanchev Dimitrov
John W. Mellors
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2019-03-24
Collections: Women's & Reproductive Health

Human Antibody Domains and Fragments to CD276

06094

engineered fully human single-domain antibodies and Fabs targeting CD276 (B7-H3) for potent, broadly applicable cancer immunotherapy.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - mAb
Therapeutic Areas: Oncology
Therapeutic Indications: Melanoma
Prostate cancer / adenocarcinoma
Glioblastoma
Lead Inventor: Dimiter Dimitrov
All Tech Innovators: Dimiter Stanchev Dimitrov
Dontcho V. Jelev
John W. Mellors
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2022-07-06

Antibody Domains that bind to Neutrophil Elastase (NE) polypeptides

05643

Antibody domains targeting neutrophil elastase inhibit its activity, offering cancer and inflammatory disease therapy with ADC potential.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - mAb
Therapeutic Areas: Oncology
Therapeutic Indications: Ductal carcinoma (Breast cancer)
Lung cancer - other
Lead Inventor: Dimiter Dimitrov
All Tech Innovators: Dusan Baek
Xiaojie Chu
Dimiter Stanchev Dimitrov
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2021-03-17
Collections: Women's & Reproductive Health

Fully Human Fabs to CD22 (bCAT1)

04874

Fully human anti-CD22 D7 binders enable CAR-T and ADCs for B-cell cancers, targeting proximal epitopes for enhanced efficacy.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - Fab
Therapeutic Areas: Oncology
Therapeutic Indications: Lymphoma
Leukemia
Lead Inventor: Dimiter Dimitrov
All Tech Innovators: Dusan Baek
Dimiter Stanchev Dimitrov
Wei Li
Technology Readiness Level: 2. Initial proof of concept, in-vitro
Date Submitted: 2019-01-27

Novel Human Antibody Domains for Disease Treatment

05621

Fully human antibody domains targeting diverse cancers; improved penetration, specificity, and potential broad therapeutic uses.

Technology Type: Therapeutic Modality
Technology Subtype: Antibody - scFV
Therapeutic Areas: Oncology
Therapeutic Indications: Acute Myeloid Leukemia (AML)
Acute Lymphoblastic Leukemia (ALL)
Lead Inventor: Dimiter Dimitrov
All Tech Innovators: Dimiter Stanchev Dimitrov
Terry Fry
Wei Li
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2021-02-18
Collections: Women's & Reproductive Health