Novel Prediction Method of Dominant Viral Strains06246A data-driven epidemiological model rapidly predicts dominant viral strains from genomic data to guide vaccine design.Technology TypeDigital HealthTechnology SubtypeHealthcare DeliveryTherapeutic AreasInfectious DiseaseTherapeutic IndicationsCovid-19InfluenzaLead InventorJohn BartonDepartmentMed-Computational and Systems BiologyAll Tech InnovatorsJohn Paul BartonDate Submitted2022-12-09
Non-Replicating SARS-CoV-2 for Safer Research06926Replication-defective SARS-CoV-2 enables safer, single-cycle research at BSL-2, with reporter genes for studies and vaccine insights.Technology TypeLife Science Research ToolTechnology SubtypeNucleic AcidTherapeutic AreasInfectious DiseaseTherapeutic IndicationsCovid-19TagsLife ScienceLead InventorZandrea AmbroseDepartmentMed-Microbiology and Molecular GeneticsAll Tech InnovatorsZandrea AmbroseHannah Leah FischerChristopher J. KlineDate Submitted2024-10-16
Novel Neutralizing Nanobodies for Coronavirus Diseases05802Pan-sarbecovirus nanobodies enable inhalable, stable, cost-effective COVID-19 and related coronavirus neutralization across variants.Technology TypeTherapeutic ModalityTechnology SubtypeOther Therapeutic ModalityTherapeutic AreasInfectious DiseaseTherapeutic IndicationsCovid-19OtherLead InventorYi ShiDepartmentMed-Cell BiologyAll Tech InnovatorsYi ShiYufei XiangDate Submitted2021-09-06
Insertion Unique to SARS-CoV-2 Exhibits Superantigenic Characteristics05404SARS-CoV-2 spike contains a unique superantigen-like site; monoclonal antibodies may block MIS-C, cytokine storms, and entry.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Discovery - TargetTherapeutic AreasInfectious DiseaseTherapeutic IndicationsCovid-19Lead InventorIvet BaharDepartmentBiochemistry and Cell BiologyAll Tech InnovatorsMoshe Arditi MDIvet BaharHongying ChengDate Submitted2020-06-05
Universal Vaccine for SARS-CoV-2 (COVID 19)05356Universal vaccine approach targets SARS-CoV-2 RdRp activation motif, potentially halting replication across coronaviruses.Technology TypeTherapeutic ModalityTechnology SubtypeSmall MoleculeTherapeutic AreasInfectious DiseaseTherapeutic IndicationsCovid-19Lead InventorPatrick MooreDepartmentMed-PathologyAll Tech InnovatorsYuan ChangPatrick S. MooreMasahiro ShudaDate Submitted2020-05-13
Human Monoclonal Antibodies against SARS-CoV-205259Neutralizing human monoclonal antibodies target SARS-CoV-2 spike RBD, blocking entry or directing infected-cell killing.Technology TypeTherapeutic ModalityTechnology SubtypeAntibody - mAbTherapeutic AreasInfectious DiseaseTherapeutic IndicationsCovid-19Lead InventorDimiter DimitrovAll Tech InnovatorsChuan ChenDimiter Stanchev DimitrovDontcho V. JelevTechnology Readiness Level2. Initial proof of concept, in-vitroDate Submitted2020-02-26
Rapid COVID-19 Antigen Test05627Rapid, five-minute COVID-19 antigen test using sc-SWCNT FETs for rapid, accessible, point-of-care detection.Technology TypeDiagnostic/AssayTechnology SubtypeIn vitro DiagnosticTherapeutic AreasInfectious DiseaseTherapeutic IndicationsCovid-19Lead InventorAlexander StarDepartmentChemistryAll Tech InnovatorsWenting ShaoMichael R. ShurinAlexander StarDate Submitted2021-03-04
A New Therapeutic and Diagnostic Target for SARS-CoV-2 and COVID-1905288Targeting NCOA7 to block SARS-CoV-2 entry; genotype-guided therapies and diagnostics for infection risk and severity.Technology TypeTherapeutic ModalityTechnology SubtypeDrug Discovery - TargetTherapeutic AreasInfectious DiseaseTherapeutic IndicationsCovid-19Lead InventorStephen ChanDepartmentMed-MedicineAll Tech InnovatorsStephen Yu-Wah Chan MD, PhDLloyd David HarveyTechnology Readiness Level2. Initial proof of concept, in-vitroDate Submitted2020-03-30
Rat Monoclonal Antibody to SARS CoV2 RdRp05697Novel rat monoclonal antibody targets SARS-CoV-2 RdRp, enabling multi-technique research, diagnostics, and drug discovery.Technology TypeTherapeutic ModalityTechnology SubtypeAntibody - mAbTherapeutic AreasInfectious DiseaseTherapeutic IndicationsCovid-19Lead InventorPatrick MooreDepartmentMed-PathologyAll Tech InnovatorsYuan ChangPatrick S. MooreTechnology Readiness Level2. Initial proof of concept, in-vitroDate Submitted2021-05-19
Quantification of Disease Severity Using 2D X-Ray05478Novel CNN method quantifies thoracic disease extent from 2D X-rays, using 3D CT ground truth for accuracy.Technology TypeMedical DeviceTechnology SubtypeDiagnostic ImagingTherapeutic AreasRespiratoryInfectious DiseaseTherapeutic IndicationsCovid-19EmphysemaPneumococcalLead InventorJiantao PuDepartmentMed-RadiologyAll Tech InnovatorsJiantao PuTechnology Readiness Level4. Prototype testing and refinementDate Submitted2020-08-12
A Novel Chemokine-based Treatment for Covid-19 and Fibrosis05551FibroKine™: chemokine peptides that inhibit fibrosis in COVID-19 and organ failure, offering multi-mechanism anti-fibrotic therapy.Technology TypeDiagnostic/AssayTechnology SubtypeIn vitro DiagnosticTherapeutic AreasInfectious DiseaseTherapeutic IndicationsCovid-19Lead InventorCecelia Yates-BinderDepartmentNurs-Nurse AnesthesiaAll Tech InnovatorsMonte S. WillisCecelia Christina Yates-BinderDate Submitted2020-11-11
Modified Polynucleotides Encoding the SARS-CoV-2 Spike Protein for Safer Designs06074Modified polynucleotides target SARS-CoV-2 spike motif to reduce α7nAChR suppression, potentially alleviating long COVID symptoms.Technology TypeTherapeutic ModalityTechnology SubtypeVaccine - mRNATherapeutic AreasInfectious DiseaseTherapeutic IndicationsCovid-19TagsPolymerLead InventorPei TangDepartmentMed-Anesthesiology and Perioperative MedicineAll Tech InnovatorsPei TangTommy Stevens TillmanYan XuTechnology Readiness Level2. Initial proof of concept, in-vitroDate Submitted2022-06-23
Individual Biocontainment Unit to Reduce Viral Transmission05295Ultra-low-cost, off-the-shelf biocontainment hood for single-patient use to reduce viral spread in hospitals and field settings.Technology TypeMedical DeviceTechnology SubtypeOther Medical DeviceTherapeutic AreasIntensive CareInfectious DiseaseTherapeutic IndicationsCovid-19Lead InventorJoseph RubinDepartmentMed-Plastic SurgeryAll Tech InnovatorsHeng BanJason S. ChangLucas A. DvoracekTechnology Readiness Level3. Prototype developmentDate Submitted2020-04-07
