University of Pittsburgh researchers have demonstrated that MMS350, a water-soluble sulfoxide and hydroxyl radical scavenger, can significantly enhance bone healing following irradiation or even without irradiation. MMS350 mitigates the damage caused by irradiation by scavenging hydroxyl radicals and other reactive oxygen species, thereby accelerating the bone healing process. This technology holds promise for improving bone repair in patients undergoing radiation therapy for cancers, as well as in cases of combined injuries from nuclear incidents.
Mice whose legs were or were not irradiated were treated with MMS-350 or vehicles; wounds were measured by radiography (J Radio Prot, 2024).
Description
MMS350, is a hydroxyl radical scavenger that can be administered orally or via a single intraperitoneal injection. By increasing antioxidant levels in cells, MMS350 reduces secondary damage caused by irradiation and speeds up the recovery process, including bone healing. This technology is particularly beneficial for children receiving radiation therapy for cancers like sarcomas, as well as adults with bone cancers or metastases requiring radiation.
Applications
• Enhancing bone healing in patients undergoing radiation therapy
• Treating bone fractures in children and adults
• Mitigating bone damage in cases of nuclear incidents
• General bone repair and regenerative medicine
Advantages
MMS350 is water-soluble and can be administered orally, unlike many other drugs developed for radiation damage mitigation that require injections. In studies, MMS350 has shown no toxicity when administered to mice for over 200 days. The ability to enhance bone healing in both irradiated and non-irradiated conditions make MMS350 a versatile and valuable tool in regenerative medicine.
Invention Readiness
The technology has been tested in vivo, demonstrating its effectiveness in enhancing bone healing following irradiation or without irradiation. MMS350 is ready for further development and commercialization, with potential applications in various medical fields.
IP Status
https://patents.google.com/patent/US10251860B2
