Two mouse monoclonal antibodies, clones 1D4 and 3B5, have been developed to specifically target the alpha-parvin protein using a GST fusion protein containing human alpha-parvin residues 29‑372 as an immunogen. Clone 1D4 is optimized for applications such as immunoprecipitation—where it co-precipitates alpha-parvin along with ILK and PINCH—immunofluorescent staining, immunohistochemistry, and ELISA, while clone 3B5 is highly effective for Western blotting and ELISA. Both antibodies are capable of cross-reacting with alpha-parvin from human, mouse, and hamster, making them versatile tools in studies of integrin signaling, cytoskeletal remodeling, cellular migration, proliferation, and survival.
Description
These tools are differentiated by their distinct functionalities and broad species reactivity. The ability of clone 1D4 to capture the ILK-PINCH-alpha-Parvin complex adds significant value in dissecting focal adhesion complexes, an essential aspect of cellular dynamics.
Applications
- Diagnostic assay development
- Drug discovery screening
- Protein interaction analysis
- Cell adhesion research tool
Advantages
- Enables versatile experimental applications including immunoprecipitation, - immunofluorescence, immunohistochemistry, ELISA, and Western blotting.
- Facilitates the study of the ILK-PINCH-alpha-Parvin focal adhesion complex and associated cellular signaling pathways.
- Exhibits cross-species reactivity, allowing for research across human, mouse, and hamster models.
- Supports investigations into key cellular processes such as integrin signaling, cytoskeletal remodeling, cell migration, proliferation, and survival.
IP Status
Research Tool
