This wet‐electrospun approach is distinct from conventional dry electrospinning because it integrates bioactive components directly during fiber formation, rather than post‐fabrication. The simultaneous deposition of liquid and polymer creates a scaffold with superior cell‐scaffold interactions, enhanced nutrient delivery and improved mimicry of native tissue mechanics. In vivo studies demonstrate that these matrices outperform dry electrospun constructs and expanded polytetrafluoroethylene controls, exhibiting extensive host cell ingrowth, robust extracellular matrix elaboration and development of native‐like anisotropic mechanical behavior.
Description
A concurrent solution electrospray/polymer electrospinning method is developed to obtain a wet-electrospun biodegradable fibrous scaffold. This novel wet-electrospun scaffold is generated to markedly improve the cellular and tissue integration. This scaffold would pave the way for cells and tissue penetration inside. The bioactive molecules contained in the electrosprayed solution would also motivate the cellular infiltration and tissue remodeling.
Applications
Abdominal wall reconstruction
Cardiac tissue repair
Soft tissue regeneration
Cell culture scaffolds
Vascular graft fabrication
Advantages
Enhanced cellular infiltration and tissue integration
Tunable mechanical properties (isotropic or anisotropic) to mimic native tissues
Direct incorporation of bioactive components (proteins, growth factors, cells)
Biodegradability supporting scaffold remodeling and extracellular matrix deposition
Improved in vivo repair outcomes for soft tissue defects (abdominal wall, cardiac)
IP Status
https://patents.google.com/patent/US9901659B2
