This wet‐electrospun approach is distinct from conventional dry electrospinning because it integrates bioactive components directly during fiber formation, rather than post‐fabrication. The simultaneous deposition of liquid and polymer creates a scaffold with superior cell‐scaffold interactions, enhanced nutrient delivery and improved mimicry of native tissue mechanics. In vivo studies demonstrate that these matrices outperform dry electrospun constructs and expanded polytetrafluoroethylene controls, exhibiting extensive host cell ingrowth, robust extracellular matrix elaboration and development of native‐like anisotropic mechanical behavior.