Bioreactor for Physiologic Loading of Epithelialized Hollow Organs

Description

A bioreactor system has been constructed to provide cyclic distention to two tubular tissue constructs. The luminal flow loop will provide intraluminal pressure and will have the potential to support epithelial/endothelial cell growth and differentiation through exposure to liquid or air flow. The abluminal loop will support a second, likely mesenchymal cell type. The magnitude of pressure that develops will can be controlled with the use of a flow resistor placed in line up stream and downstream of the construct.

IP Status

Research Tool

Quick Facts:
Reference Number
02411
Technology Type
Life Science Research Tool
Technology Subtype
Cell Line
Tags
Tissue engineering
Lead Inventor
Thomas Gilbert
Department
Bioengineering
All Tech Innovators
Thomas W. GilbertMark JuhasNathaniel Thomas Remlinger
Date Submitted
2011-02-21