Description
The inventors have developed a modified form of flux balance analysis that incorporates a solvent capacity constraint for the attainable enzyme concentrations within the crowded cytoplasm. Using this model they are able to successfully predict the maximum growth rate of wild type and mutant bacterial cells on single carbon sources, the dynamic patterns of substrate utilization from a mixed-substrate growth medium, and the global reorganization of metabolic activity in cells when they are shifted from low to high growth rates.This Invention is believed to represent a substantial extension of flux balance-based modeling capabilities, and as such will be of interest to the biotechnology and biomodeling industry.
IP Status
https://patents.google.com/patent/US9449144B2