This technology combines vascular cell types, such as endothelial cells and pericytes, within a self-organizing 3D brain organoid structure that develops a functional blood-brain barrier. It features a unique design that promotes organoid maturation and viability over long-term studies, enabling researchers to explore intricate cellular interactions. The platform replicates the brain’s complex microenvironment more accurately than traditional 2D cultures, supporting studies of neurodegenerative and neuroviral conditions by closely mimicking in vivo tissue cytoarchitecture and cellular composition.
Description
The approach stands apart by integrating a realistic blood-brain axis absent in previous models, offering a physiologically relevant platform for preclinical research. Its ability to simulate the dynamic interplay between brain tissues and the vascular network empowers scientists to assess treatment safety and efficacy with greater precision. By bridging a critical gap in existing models, this technology enhances our understanding of diseases like Alzheimer’s, Parkinson’s, and viral-induced neurodegeneration, thereby opening new avenues for targeted therapeutic development and advancing research into complex neurological disorders.
Applications
- Neurodegenerative disease modeling
- Neuroviral pathogenesis analysis
- Preclinical drug screening
- Blood-brain barrier assays
- Long-term organoid culture
Advantages
- Mimics the in vivo blood-brain barrier and vascular network for a more accurate replication of the brain’s microenvironment.
- Enhances organoid viability and maturation, supporting long-term studies of neurodegenerative and neuroviral diseases.
- Provides a physiologically relevant 3D platform that accurately models complex cellular interactions.
- Enables improved preclinical assessment of disease mechanisms and treatment safety/efficacy before human trials.
IP Status
Research Tool
