University of Pittsburgh researchers have developed innovative magnesium (Mg) alloy-based bone fixation devices designed to enhance bone formation and improve fracture healing. These degradable implants provide an ideal balance of strength and controlled degradation, eliminating the need for removal surgeries and mitigating complications associated with permanent metal implants. The unique design of these devices promotes localized Mg ion release, stimulating bone growth and ensuring stable fracture fixation.
The schema of degradable Mg alloys (A), and the observed Mg device degradation, with uninhibited healing in bone growth (B).
Description
The novel bone fixation devices are made from degradable Mg alloys, which offer optimal mechanical properties for bone applications, such as low density, high fracture toughness, and compressive strength similar to cortical bone. The devices include fixation plates and screws with a unique tapered thread form that provides necessary stabilization while promoting degradation at the thread tips. This controlled degradation results in a burst release of Mg ions, which stimulates localized bone formation and enhances osteointegration. The devices are designed to maintain fracture stability throughout the healing process and gradually degrade, being replaced by natural bone over time.
Applications
• Orthopedic and craniomaxillofacial bone fixation
• Load-bearing fracture applications
• Fixation of membranes or meshes used for bone augmentation
Advantages
The Mg alloy-based fixation devices are degradable, avoiding long-term complications and the need for removal surgery. They stimulate local bone formation, enhancing healing and load-bearing capabilities. The unique tapered thread form promotes controlled degradation and Mg ion release, while bone-like mechanical properties reduce stress shielding. The devices are radiolucent for clear imaging and user-friendly with self-tapping screws for easy surgical procedures.
Invention Readiness
The technology has been developed and tested in vivo, demonstrating its effectiveness in enhancing bone formation and providing stable fracture fixation. The devices are ready for further development and commercialization, with potential applications in various orthopedic and craniomaxillofacial procedures.
IP Status
https://patents.google.com/patent/US11317955B2
