Mitochondria-Targeted Specific Inhibitors of Cytochrome C Peroxidase Activity and Cardiolipin Oxidation as Protectors and Mitigators of Radiation Injury

Description

The present application relates to novel compounds that inhibit cytochrome c (cyt c) peroxidase, compositions comprising these compounds and various uses thereof, for example for protection of cells from apoptosis. In particular, the present application relates to novel imidazole-substituted fatty acids and their use as cyt c peroxidase inhibitors.

IP Status

https://patents.google.com/patent/US9365597B2

Quick Facts:
Reference Number
02481
Technology Type
Therapeutic Modality
Technology Subtype
Small Molecule
Therapeutic Areas
Oncology
Lead Inventor
Valerian Kagan
Department
GSPH-Environmental/Occupational Health
All Tech Innovators
Jeffrey Atkinson PhDMichael W. Epperly Ph.D.Joel S. Greenberger M.D.Valerian E. Kagan PhD, DScDetcho Anastassov Stoyanovsky PhD
Date Submitted
2011-05-12