Muscle-Derived Stem/Progenitor Cells for Tissue Regeneration & Lifespan Extension

The natural course of aging, as well as the progression of several degenerative diseases, closely correlates with a loss of adult stem cell quantity and function. Adult stem cells exist in nearly all tissue types in the body and are responsible for maintaining normal tissue turnover and regenerating damaged or injured tissues. Stem cells maintain and repair tissues by reproducing, differentiating into other cell types, and releasing growth and signaling factors to regulate the behavior of nearby cells. Injecting muscle-derived stem cells harvested from young mice can recover the loss of stem cell proliferation and function observed in older mice, and in addition to anti-aging applications, mice with simulated Hutchinson-Gilford progeria syndrome significantly extended lifespan and improved health after stem cell injection. This indicates the therapeutic potential of stem cells from younger donors or stem cells banked early in a patient’s life to ameliorate the symptoms of degenerative diseases or aging.

Description

This technology is a therapeutic method of administering autologous or allogenic stem cells isolated from younger donors in order to restore or rejuvenate adult stem cell function. This technology offers therapeutic potential by administering isolated allogenic healthy adult stem cells and an mTOR inhibitor and releasing secreted growth and signaling factors from those stem cells into a degenerative or injured tissue. After administration, these therapies rejuvenate these damaged tissues in otherwise healthy mammals and delay or reverse signs of aging-related symptoms such as progeria.

Applications

· Anti-aging
· Treating the symptoms of degenerative diseases, like Hutchinson-Gilford progeria syndrome.

Advantages

· Stem cell transplants eliminate the need for pharmacologic therapies
· Delays progression of degenerative progeria-type syndromes

Invention Readiness

In vivo data

IP Status

https://patents.google.com/patent/US9295696B2; https://patents.google.com/patent/US10293001B2

Related Publications

Lavasani, M., Robinson, A. R., Lu, A., Song, M., Feduska, J. M., Ahani, B., Tilstra, J. S., Feldman, C. H., Robbins, P. D., Niedernhofer, L. J., & Huard, J. (2012). Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model. Nature Communications, 3(1). https://doi.org/10.1038/ncomms1611