Novel Metabolomic Markers in Sepsis and Pneumonia

Description

This invention is related to global metabolomic profiling in subjects hospitalized with pneumonia and sepsis who died at 90 days compared to survivors. These data revealed physiologically relevant metabolites, consistent with known complex processes in early sepsis (e.g., for example, bile acid metabolism, protein catabolism, inflammation, and/or oxidative stress) that were different in patients versus controls. Moreover, the data demonstrate a potential for metabolomic signatures to uncover novel markers in sepsis, though quantification and validation.

IP Status

https://patents.google.com/patent/US10533989B2

Related Publication(s)

Kapp, K. L., Choi, M. J., Bai, K., Du, L., Yende, S., Kellum, J. A., Angus, D. C., Peck-Palmer, O. M., & Robinson, R. A. S. (2023). Pathways Associated with Positive Sepsis Survival Outcomes in African American/Black and Non-Hispanic White UTI Patients. Shock. https://doi.org/10.1097/shk.0000000000002176

Kapp, K. L., Arul, A. B., Zhang, K. C., Du, L., Yende, S., Kellum, J. A., Angus, D. C., Peck-Palmer, O. M., & Robinson, R. A. S. (2022). Proteomic changes associated with racial background and sepsis survival outcomes. Molecular Omics, 18(10), 923–937. https://doi.org/10.1039/d2mo00171c

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