Description
Novel synthetic peptides have been developed that are capable of recruiting endogenous progenitor cells to sites of injury to promote tissue healing and reconstruction. Previous studies have revealed that implantation of solid porcine urinary bladder extracellular matrix (UBM) promotes tissue regeneration and constructive remodeling, which is due, in part, to the degradation of the UBM construct in the patient. This degradation releases peptides that promote an increase in the presence of progenitor cells at the site of implantation. Analytical methods were used to identify the peptides responsible for progenitor cell recruitment. Synthetic versions of these identifiedpeptides allow for the relocation of patient specific multi-potent progenitor cells to the site of injury without the practical and ethical challenges of harvesting and implanting stem cells. These peptides therefore serve as novel wound healing and/or tissue regeneration therapeutics.
IP Status
https://patents.google.com/patent/US9340602B2