Restorative Neurophysiology: A System for Re-achieving Previous Neurological States

This invention is a system and method for restoring an individual to a previously assessed neurological state. It offers an innovative and personalized approach to therapy by utilizing a person's own unique brain state as the target for restoration.

Description

The invention operates by first capturing an individual's baseline brain state using electroencephalography (EEG). This process records multi-frequency waveform data from various locations on the scalp, which is then stored. At a later time, the system uses this stored waveform data to generate and deliver customized transcranial alternating current stimulation (TACS) to the individual. This stimulation is provided through electrodes positioned similarly to those used during the assessment, effectively "restoring" the individual's brain state to the captured baseline. The stimulation can be dynamically adjusted via closed-loop feedback to more accurately match the original signal.

Applications

- First responders and soldiers who may experience a trauma situation.
- Individuals with predictable mood variations, such as seasonal depression.
- People with premenstrual dysphoric disorder (PMDD).
- As a restorative therapy for psychiatric conditions.

Advantages

- Enables personalized, or "idiosyncratic," restorative therapy by targeting an individual's unique brain state rather than a generic template.
- The system can be used to capture and "back up" a person's healthy, pre-episode brain state for later restoration.
- Combines multiple physiological modalities, including brain state, facial muscle activity, respiration, heart rate variability, and vocalization parameters for a more comprehensive assessment.
- Uses direct stimulation to achieve the desired brain state immediately.
- The system is non-invasive, using external electrodes for both assessment and stimulation.

Invention Readiness

The technology is in a proof-of-concept stage, with research demonstrating the ability to capture and restore brain states. Data has been generated showing that two sessions of fMRI neurofeedback can have sustained training effects. Further studies are needed to validate the full system and its application in specific populations.

IP Status

Patent Pending

Related Publication(s)

Neurodata Refinement. (n.d.). [Video]. YouTube. Retrieved August 13, 2025, from https://www.youtube.com/@NeurodataRefinement

Siegle, G., & Young, K. (n.d.). Restoring the brain to its previous neurophysiology [Audio podcast episode]. In Psychiatry advances podcast. UPMC Western Psychiatric Hospital. https://www.upmc.com/locations/hospitals/western-psychiatric/training-education/podcast/restoring-the-brain-to-its-previous-neurophysiology