Semapimod Inhibits the Expression of the Proapoptotic and Proinflammatory Proteins HMGB1, Bad, Bax and COX-2

Description

University of Pittsburgh researchers have found that daily administration of semapimod decreases the protein expression of HMGB1, Bad, Bax and COX-2 in the intestines of formula-fed newborn rats exposed to hypoxia and protects against chronic intestinal injury in an animal model of necrotizing enterocolitis (NEC).

IP Status

https://patents.google.com/patent/US8314149B2

Quick Facts:
Reference Number
01087
Technology Type
Therapeutic Modality
Technology Subtype
Small Molecule
Therapeutic Areas
Gastroenterology
Therapeutic Indications
Other
Tags
Drug Repurposing
Lead Inventor
Ruben Zamora
Department
Med-Surgery
All Tech Innovators
Henri R. FordRuben Zamora
Date Submitted
2005-04-15