Small Molecule Antagonists of HIV Nef Function

Quick Facts:
Reference Number: 02843
Technology Type: Therapeutic Modality
Technology Subtype: Small Molecule
Therapeutic Areas: Infectious Disease
Therapeutic Indications: HIV
Lead Inventor: Thomas Smithgall
Department: Med-Microbiology and Molecular Genetics
All Tech Innovators: Billy W. Day, Lori Ann Emert-Sedlak, Prema Chandrasekhar Iyer, Thomas E. Smithgall, Jielu Zhao
Date Submitted: 2012-07-25
Collections: Women's & Reproductive Health

Description

Disclosed herein are embodiments of a compound capable of treating HIV. In particular disclosed embodiments, the compound is capable of inhibiting Nef, such as by acting as antagonists of HIV Nef function. Also disclosed are embodiments of a method of making the compound, embodiments of a method of using the compound, and embodiments of a method of identifying HIV Nef antagonists. The disclosed compound may be used alone or in combination with other pharmacologically active agents in order to promote reducing drug resistance and/or cumulative toxicity.

IP Status

https://patents.google.com/patent/US9695127B2