Small Molecule Antagonists of HIV Nef Function

Description

Disclosed herein are embodiments of a compound capable of treating HIV. In particular disclosed embodiments, the compound is capable of inhibiting Nef, such as by acting as antagonists of HIV Nef function. Also disclosed are embodiments of a method of making the compound, embodiments of a method of using the compound, and embodiments of a method of identifying HIV Nef antagonists. The disclosed compound may be used alone or in combination with other pharmacologically active agents in order to promote reducing drug resistance and/or cumulative toxicity.

IP Status

https://patents.google.com/patent/US9695127B2

Quick Facts:
Reference Number
02843
Technology Type
Therapeutic Modality
Technology Subtype
Small Molecule
Therapeutic Areas
Infectious Disease
Therapeutic Indications
HIV
Lead Inventor
Thomas Smithgall
Department
Med-Microbiology and Molecular Genetics
All Tech Innovators
Billy W. DayLori Ann Emert-SedlakPrema Chandrasekhar IyerThomas E. SmithgallJielu Zhao
Date Submitted
2012-07-25
Collections
Women's & Reproductive Health