Women's & Reproductive Health - University of Pittsburgh

Search text

75 results

(0.07 seconds)

Non-Invasive Detection of HPV+ and Throat Cancers

06558

In recent years, HPV vaccines and pap smears have reduced the rates of genital HPV+ cancers.

• Other HPV+ oropharyngeal cancers.

This liquid biopsy could be assessed for biomarkers of HPV+ cancers including analysis of cfDNA using NGS techniques.

Jose Zevallos

Diagnostic/Assay

Other Diagnostic/Assay

Oncology

2023-11-03

Biofabricated Vaginal Extracellular Matrix Hydrogel

06412

Extirpative surgeries, radiation treatment, congenital anomalies, ovariectomy, menopause, aging, chemotherapy, and vaginal birth trauma can all result in loss or impairment of vaginal structure and function.

Extirpative surgeries, radiation treatment, congenital anomalies, ovariectomy, menopause, aging, chemotherapy, and vaginal birth trauma can all result in loss or impairment of vaginal structure and function.

Researchers at Pitt developed a novel hydrogel biofabricated from porcine vaginal extracellular matrix (vECM) and its potential applications in the field of Urogynecology.

Pamela Moalli

2023-05-17

Novel Immunotherapy for Hepatocellular Carcinoma

06382

University of Pittsburgh researchers have identified a novel extracellular protein domain in hepatocellular carcinoma (HCC) and developed a monoclonal antibody (mAb) to recognize this target.

4Antibody - mAb Drug Discovery - Target Immunology

2023-04-21

Novel Human Antibody Domains for Disease Treatment

06240

· Brain cancer. · Ovarian cancers. · Breast cancers. · Pediatric medulloblastoma.

2022-12-06

Innovative Small Molecule for Zika Virus Neutralization

06214

Investigation of the presence of antibodies against Zika prior and during pregnancy is very important to implement infection prevention measures and to determine the viral infection of the mother.

2022-11-14

New Test Can Predict Immunotherapy Responders for Broader Range of Cancers than Current Tools

06200

Through Pan-Cancer Analysis of Whole Genomes, it has been found that IGR burden is a pivotal contributor to increased T-inflamed signature in selected tumor entities such as breast cancer, ovarian cancer, uterine corpus endometrial cancer, and esophageal adenocarcinoma, and correlates with increased type-I immune response effectors, such as Macrophage M1 and CD8+ T cells.

Xiaosong Wang

Diagnostic/Assay

Other Diagnostic/Assay

Oncology

2022-10-31

EndoRX: Revolutionizing Early Endometriosis Diagnosis with Machine Learning

06181

University of Pittsburgh researchers have developed EndoDx, a groundbreaking diagnostic tool that leverages machine learning to diagnose endometriosis (EM) early and non-invasively.

This model predicts the presence and severity of endometriosis, offering a non-invasive alternative to surgical diagnosis.

• Diagnostic tool for endometriosis.

Isabelle Chickanosky

2022-10-07

Novel FOXM1 Inhibitors to Assist Cancer Treatment

06168

In vitro data confirm STL001’s ability to sensitize diverse cancer cell lines to chemotherapy, including AML, triple-negative breast cancer, colorectal, ovarian, and prostate cancers.

• Triple-Negative and Tamoxifen-Resistant Breast Cancer.

2022-09-27

Development of WCRC-25, an Invasive Lobular Carcinoma Cell Line

06163

Established in a controlled laboratory environment with rigorous consent protocols, it has been meticulously developed to serve as an effective in vitro platform for studying breast cancer biology and therapeutic responses.

This tool has gained recognition in prominent scientific forums and is being shared with the broader research community through established agreements, enhancing collaborative efforts to advance treatment strategies for breast cancer.

- Addresses a critical gap in available breast cancer research models, particularly for ER-negative ILC.

Steffi Oesterreich

Life Science Research Tool

Cell Line

Oncology

Breast cancer

2022-09-14

Novel Approach to Immunotherapy in Ovarian Cancer

06112

Ovarian cancer (OC) can be a devastating disease, due to rare symptoms resulting in diagnosis often only when cancer is at an advanced stage and has spread.

This approach has the potential to improve outcomes in patients with OC. Applications. • Ovarian cancer immunotherapy. • Protection of intestines from radiotherapy.

Ovarian cancerOther

Immuno-oncology

2022-07-27

Novel Approach to Bone Regeneration

06099

This approach has shown the potential of both surgical and chemical approaches to “activate” SSCs present in humans to promote regeneration of bone in the absence of biomaterial implants or other osteogenic tissue implants. Applications. • Osteoporosis prevention. • Traumatic bone injuries. • Congenital bone abnormalities.

Giuseppe Intini

Therapeutic Modality

Small Molecule

Dental Musculoskeletal

Regenerative medicine

2022-07-13

Novel Immortal Antibody Secreting Cell Lines

06101

These patient-derived novel cell lines have the potential to identify therapeutic targets in ovarian cancer.

Using tissue from different high-grade serous epithelial ovarian cancer (EOC) patients, four unique antibody secreting plasma cell lines were isolated.

Anda Vlad

Life Science Research Tool

Cell Line

Oncology

Ovarian cancer

2022-07-13

Transgenic Mice Expressing Human C19MC

06008

C19MCs are normally only expressed in the placenta during pregnancy, but abnormal expression has been associated with rare forms of cancers, particularly pediatric brain tumors.

Further research could build on this discovery to develop blood-based diagnostics of pregnancy complication related to placental dysfunction.

Yoel Sadovsky

Life Science Research Tool

Animal Model

Reproductive Health

Obstetrics

2022-04-18

A Pain-enabled in vitro System for Studying Pain Mechanisms and Developing Treatments

05994

Researchers at Pitt have developed a pain-enabled in vitro system to study pain mechanisms and develop treatments specifically related to osteoarthritis (OA) and its associated pain.

Hang Lin

Life Science Research Tool

Cell Line

Musculoskeletal Neuroscience

OsteoporosisPain

2022-03-28

Novel Immune-Stimulating Virus for Cancer Therapy

05986

University of Pittsburgh researchers have discovered that Vesicular Stomatitis Virus G glycoprotein (VSV G) can be modified to specifically target cancer cells expressing the transmembrane glycosylated tyrosine kinase, HER2/neu.

Breast cancer

2022-03-16