All Tech Innovators

William R. Wagner PhD

New Permanent Treatment for Cerebral Aneurysms

06726

Injectable, ECM-derived embolic seals aneurysms permanently, integrating with tissue to avoid coils, recanalization, and retreatment.

Technology Type: Therapeutic Modality
Therapeutic Areas: Hematology
Lead Inventor: Seungil Kim
Department: Bioengineering
All Tech Innovators: Seungil Kim
William R. Wagner PhD
Date Submitted: 2024-04-25
Collections: Regenerative Medicine

Novel Small-Diameter Vascular Graft for Tissue Engineering

04295

Three-layer, bio-inspired 2–3 mm TEVGs mimic coronary arteries, combining ES, cECM, and TIPS for scalable grafts.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Cardiovascular
Lead Inventor: Antonio DAmore
Department: Med-Surgery
All Tech Innovators: Antonio DAmore
Matteo Solazzo
William R. Wagner PhD
Date Submitted: 2017-06-14
Collections: Cardiometabolic

Thermoresponsive, Biodegradable, Elastomeric Material

01315

Biodegradable, thermoresponsive hydrogel that is injectable, ultra-flexible, and shapes with temperature for tissue engineering and drug delivery.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Tags: Biomaterial
Regenerative medicine
Tissue engineering
Lead Inventor: William Wagner
Department: Bioengineering
All Tech Innovators: Jianjun Guan
William R. Wagner PhD
Date Submitted: 2006-09-14
Collections: Regenerative Medicine

Novel Processing Method and Apparatus for Micro-Structured Rope-Like Material

04694

Continuous mandrel-less electrospun ropes with tunable diameter and fiber orientation for regenerative tendon, nerve, and suture applications.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Musculoskeletal
Tags: Polymer
Tissue engineering
Lead Inventor: Antonio DAmore
Department: Med-Surgery
All Tech Innovators: Antonio DAmore
Daniel T. McKeel
William R. Wagner PhD
Date Submitted: 2018-07-30
Collections: Regenerative Medicine

A Novel Biohybrid Composite Scaffold

02205

Elastic biohybrid scaffold combining ECM gel and electrospun elastomer fibers for improved integration and support.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Tags: Biomaterial
Tissue engineering
Lead Inventor: Yi Hong
All Tech Innovators: Stephen Francis Badylak DVM, PhD, MD
Ryotaro Hashizume
Yi Hong
Date Submitted: 2010-04-27
Collections: Regenerative Medicine

Biohybrid Elastomeric Scaffolds for Wound Healing and Tissue Regeneration

01174

Biohybrid elastomeric scaffolds merge synthetic and biological polymers to enhance wound healing and tissue regeneration.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Tags: Biomaterial
Regenerative medicine
Tissue engineering
Lead Inventor: William Wagner
Department: Bioengineering
All Tech Innovators: Stephen Francis Badylak DVM, PhD, MD
Donald O. Freytes MSBME
Thomas W. Gilbert
Date Submitted: 2005-11-16
Collections: Regenerative Medicine

Hybrid Scaffolds for Bone Defect Regeneration

04114

Hybrid Mg alloy–polymer/DBM scaffold enables osteogenic bone regeneration for critical-sized defects, reducing grafting risks.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Musculoskeletal
Tags: Biomaterial
Regenerative medicine
Life Science
Lead Inventor: William Wagner
Department: Bioengineering
All Tech Innovators: Yingqi Chen
Vesselin N. Shanov
William R. Wagner PhD
Date Submitted: 2016-12-12
Collections: Regenerative Medicine

A Biodegradable, Porous, Thermally Responsive Injectable Hydrogel as Soft Tissue Defect Filler

04040

Biodegradable, injectable hydrogel with in situ gelation, porosity, ECM cues, and rapid tissue regeneration for soft-tissue repair.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Tags: Biomaterial
Regenerative medicine
Tissue engineering
Lead Inventor: William Wagner
Department: Bioengineering
All Tech Innovators: Stephen Francis Badylak DVM, PhD, MD
Hong Bin Jiang
Hideyoshi Sato
Date Submitted: 2016-10-04
Collections: Regenerative Medicine

A Biodegradable, Antioxidant, Thermally Responsive Injectable Hydrogel for Treatment of Ischemic Cardiomyopathy

04039

Thermally gelling, MRI-visible, biodegradable hydrogel with covalently bonded antioxidants for injectable ischemic cardiomyopathy therapy.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Cardiovascular
Therapeutic Indications: Hypertrophic cardiomyopathy
Dialated cardiomyopathy
Tags: Biomaterial
Lead Inventor: William Wagner
Department: Bioengineering
All Tech Innovators: Yasumoto Matsumura
Murugesan Velayutham
William R. Wagner PhD
Date Submitted: 2016-10-04
Collections: Cardiometabolic

Biodegradable, Non-Thrombogenic Elastomeric Polyurethanes for Device Coatings and Other Applications

02698

Biodegradable, non-thrombogenic elastomeric polyurethanes coat devices, deliver drugs, reduce clots, and resist restenosis.

Technology Type: Engineering Technology
Technology Subtype: Material Science
Tags: Coating
Polymer
Lead Inventor: Yi Hong
All Tech Innovators: Yi Hong
William R. Wagner PhD
Sang Ho Ye
Date Submitted: 2012-02-20

A Flexible Wireless Sensor Embedded Intravaginal ring (IVR) for On-Demand Electroresponsive Release of Anti-Sexually Transmitted Infection

06042

Flexible wireless IVR detects vaginal cues and electrically releases anti-STI agents on demand for targeted prevention.

Technology Type: Medical Device
Technology Subtype: Rehab or Assistive Medical Device
Therapeutic Areas: Infectious Disease
Therapeutic Indications: HIV
Tags: Biomaterial
Sustainability
Sensor
Lead Inventor: Seungil Kim
Department: Bioengineering
All Tech Innovators: Emmanuel A. Ho
Seungil Kim
Yongkuk Lee
Date Submitted: 2022-05-31
Collections: Women's & Reproductive Health

Biodegradable Polyester Urethane Urea Cardiac Patch

01261

Biodegradable elastomeric PEUU cardiac patch grows with patient, reduces remodeling, and supports host tissue integration and recovery.

Technology Type: Medical Device
Technology Subtype: Therapeutic Medical Device
Therapeutic Areas: Cardiovascular
Tags: Biomaterial
Tissue engineering
Lead Inventor: William Wagner
Department: Bioengineering
All Tech Innovators: Kazuro Lee Fujimoto
Jianjun Guan
Bradley B. Keller
Date Submitted: 2006-05-04
Collections: Regenerative Medicine
Cardiometabolic

Biocarpet biodegradable device for vascular disease

05505

Biodegradable, flexible biocarpet device for targeted drug delivery in peripheral arteries; thermoforms in situ, reduces restenosis risk.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Cardiovascular
Lead Inventor: Jonathan Vande Geest
Department: Bioengineering
All Tech Innovators: John J. Pacella
Jonathan P. Vande Geest
William R. Wagner PhD
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2020-09-14
Collections: Cardiometabolic

Innovative NO2-OA Release Platform for Enhanced Angiogenesis in Abdominal Wall Repair

04294

Nitro-oleic acid release from PECUU-ECM scaffolds enhances regional angiogenesis for improved abdominal wall repair and integration.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Gastroenterology
Therapeutic Indications: Other
Lead Inventor: Antonio DAmore
Department: Med-Surgery
All Tech Innovators: Antonio DAmore
Marco Fazzari
Bruce A. Freeman
Date Submitted: 2017-06-14
Collections: Regenerative Medicine

An Expandable Percutaneous Venous Cannula for Use in Extracorporeal Cardiopulmonary Support

03884

Expandable single‑cannula ECMO device conforming to atrial anatomy for complete, low‑occlusion venous drainage via percutaneous deployment

Technology Type: Medical Device
Technology Subtype: Therapeutic Medical Device
Therapeutic Areas: Respiratory
Cardiovascular
Tags: Biomaterial
Polymer
Lead Inventor: Antonio DAmore
Department: Med-Surgery
All Tech Innovators: Vinay Badhwar
Antonio DAmore
Daniel T. McKeel
Date Submitted: 2016-04-04
Collections: Cardiometabolic

Topograft: Tuning Adhesion at Blood Contacting Device Interfaces

03550

Topograft uses reversible surface topography to self-clean and renew vascular graft interfaces, drastically reducing clotting and need for harvesting.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Cardiovascular
Hematology
Therapeutic Indications: Thrombosis
Lead Inventor: Sachin Velankar
Department: Chem/Petroleum Engineering
All Tech Innovators: Luka Pocivavsek
Edith Tzeng
Sachin Shankar Velankar
Technology Readiness Level: 3. Prototype development
Date Submitted: 2015-03-12
Collections: Cardiometabolic

Zwitterionic Polysiloxane & Urethane Urea Copolymers for Preventing Protein and Thrombotic Deposition

04958

Zwitterionic PDMS-urethane copolymers resist protein/thrombus deposition, enabling biocompatible, durable coatings for cardiovascular devices. (15 words)

Technology Type: Engineering Technology
Technology Subtype: Material Science
Lead Inventor: Sang Ho Ye
Department: Bioengineering
All Tech Innovators: Sung Kwon Cho
Seungil Kim
William R. Wagner PhD
Date Submitted: 2019-04-15

Bioabsorbable Metallic Alloy Coils for Aneurysm Treatment

05854

Bioabsorbable magnesium-coil aneurysm treatment with polyurethane coatings promotes healing, reduces long-term foreign-body risks, enables drug delivery.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Nephrology
Neuroscience
Lead Inventor: William Wagner
Department: Bioengineering
All Tech Innovators: Youngjae Jae Chun
Seungil Kim
Kamil W. Nowicki
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2021-10-25
Collections: Regenerative Medicine

Injectable Thermoresponsive Biodegradable Hydrogel for Tissue Support and Controlled Therapeutic Delivery

03234

Injectable, thermoresponsive, biodegradable hydrogel enabling in situ gelation, controlled drug release, tissue support, and removable via cooling.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Cardiovascular
Therapeutic Indications: Myocardial infarction
Hypertrophic cardiomyopathy
Dialated cardiomyopathy
Lead Inventor: William Wagner
Department: Bioengineering
All Tech Innovators: Hong Bin Jiang
William R. Wagner PhD
Tomo Yoshizumi
Date Submitted: 2014-02-07
Collections: Regenerative Medicine
Cardiometabolic

Novel Method for Removing Cell-Free Plasma Hemoglobin

05366

A targeted extracorporeal device removes cell-free plasma hemoglobin from blood, improving safety and efficiency of bypass and life-support.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Neuroscience
Lead Inventor: Nahmah Kim-Campbell
Department: Med-Critical Care Medicine
All Tech Innovators: Hulya Bayir
William J. Federspiel
Nahmah Anabella Kim-Campbell
Technology Readiness Level: 4. Prototype testing and refinement
Date Submitted: 2020-05-17

Biodegradable Electrospun Scaffolds for Enhanced Tissue Repair and Cellular Infiltration

02170

Biodegradable wet-electrospun scaffolds enhance tissue repair with bioactive, integrated fibers for superior cellular infiltration and mechanics.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Tags: Biomaterial
Polymer
Tissue engineering
Lead Inventor: Yi Hong
All Tech Innovators: Nicholas J. Amoroso
Kazuro Lee Fujimoto
Ryotaro Hashizume
Date Submitted: 2010-03-22
Collections: Regenerative Medicine

Accelerated Coronary Stent Endothelization Using Targeted Microbubbles

01653

Ultrasound-driven microbubble tagging accelerates targeted endothelialization on stents by steering cells to graft sites.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Cardiovascular
Therapeutic Indications: Atherosclerotic disease
Lead Inventor: Catalin Toma
Department: Med-Medicine
All Tech Innovators: Xucai Chen
Andrew Robert Fisher
Joon Sup Lee
Date Submitted: 2008-02-25
Collections: Regenerative Medicine
Cardiometabolic

Superelastic, Bioabsorbable Endovascular Devices

03179

Superelastic, mostly-biodegradable endovascular scaffold that self-expands with temperature, offers temporary support, then safely resorbs.

Technology Type: Medical Device
Technology Subtype: Implantable Medical Device
Therapeutic Areas: Cardiovascular
Tags: Biomaterial
Tissue engineering
Lead Inventor: Young Chun
Department: Industrial Engineering
All Tech Innovators: Youngjae Jae Chun
Xinzhu Gu
William R. Wagner PhD
Date Submitted: 2013-11-22
Collections: Regenerative Medicine
Cardiometabolic

Tracking Cell-Based Therapeutics in the Body with Microbubbles

01857

Ultrasound-visible microbubbles enable safe, noninvasive tracking of injected stem cells in patients, aiding trials and treatment decisions.

Technology Type: Therapeutic Modality
Technology Subtype: Drug Delivery / Formulation
Therapeutic Areas: Hematology
Oncology
Tags: Polymer
Regenerative medicine
Platform Technology
Lead Inventor: Flordeliza Villanueva
Department: Med-Medicine
All Tech Innovators: Xucai Chen
Wenjin Cui
Andrew Robert Fisher
Technology Readiness Level: 3. Initial proof of concept, in-vivo
Date Submitted: 2008-10-24
Collections: Regenerative Medicine

Biodegradable Perivascular Electrospun Polymer Wrap

01397

Biodegradable electrospun polymer wrap supports vein grafts, reducing intimal hyperplasia and improving arterial adaptation and durability.

Technology Type: Medical Device
Technology Subtype: Surgical Medical Device
Therapeutic Areas: Cardiovascular
Lead Inventor: David Vorp
Department: Bioengineering
All Tech Innovators: Mohammed Salim El-Kurdi
Yi Hong
Lorenzo Soletti
Date Submitted: 2006-12-07
Collections: Cardiometabolic

A Method to Characterize the Complete Fiber Network Topology of Planar Fibrous Tissues and Scaffolds

02193

Automated image-based tool fully characterizes engineered tissue fiber networks, detailing orientation, connectivity, intersections, density, and diameter.

Technology Type: Life Science Research Tool
Technology Subtype: Bioinformatics
Tags: Microscopy
Lead Inventor: Antonio DAmore
Department: Med-Surgery
All Tech Innovators: Antonio DAmore
Michael Steven Sacks Ph.D.
William R. Wagner PhD
Date Submitted: 2010-04-14